Structural changes in airway diseases - Characteristics, mechanisms, consequences, and pharmacologic modulation
Structural changes in airway diseases - Characteristics, mechanisms, consequences, and pharmacologic modulation
复制标题
DOI：
10.1378/chest.129.4.1068
复制
发表时间：
2006-04-01
期刊：
影响因子：
9.6
通讯作者：
Boulet, LP
中科院分区：
文献类型：
--
作者：
Bergeron, C;Boulet, LP
在气道疾病如哮喘和COPD中，可以观察到非常可能继发于潜在炎症过程的特定结构变化。尽管目前仍存在争议，但气道重塑可能有助于这些疾病的发展及其临床表现和结局。气道重塑在不同严重程度的哮喘中均有描述，并且已发现上皮下胶原或蛋白聚糖沉积增加等特征与气道反应性之间存在相关性。尽管气道重塑的临床意义仍存在争议，但已被认为是旨在降低哮喘严重程度、改善其控制并可能预防其发展的治疗的潜在靶点。迄今为止，用于治疗气道疾病的药物对气道结构变化的影响很小。应该做更多的研究来确定关键的变化，有价值的治疗方法，以及适当的干预时机来抵消这些变化。新的治疗药物逆转或预防气道重塑的潜力是一个令人兴奋的途径，值得进一步评估。
In airway diseases such as asthma and COPD, specific structural changes may be observed very likely secondary to an underlying inflammatory process. Although it is still controversial, airway remodeling may contribute to the development of these diseases and to their clinical expression and outcome. Airway remodeling has been described in asthma in various degrees of severity, and correlations have been found between such features as increase in subepithelial collagen or proteoglyean deposits and airway responsiveness. Although the clinical significance of airway remodeling remains a matter of debate, it has been suggested as a potential target for treatments aimed at reducing asthma severity, improving its control, and possibly preventing its development. To date, drugs used to treat airway diseases have a little influence on airway structural changes. More research should be done to identify key changes, valuable treatments, and proper interventional timing to counteract these changes. The potential of novel therapeutic agents to reverse or prevent airway remodeling is an exciting avenue and warrants further evaluation.