VOMERONASAL AND OLFACTORY PATHWAYS TO THE AMYGDALA CONTROLLING MALE HAMSTER SEXUAL-BEHAVIOR - AUTORADIOGRAPHIC AND BEHAVIORAL-ANALYSES
VOMERONASAL AND OLFACTORY PATHWAYS TO THE AMYGDALA CONTROLLING MALE HAMSTER SEXUAL-BEHAVIOR - AUTORADIOGRAPHIC AND BEHAVIORAL-ANALYSES
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DOI：
10.1016/0006-8993(82)90641-2
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发表时间：
1982-01-01
期刊：
影响因子：
2.9
通讯作者：
WINANS, SS
中科院分区：
文献类型：
--
作者：
LEHMAN, MN;WINANS, SS
先前的研究表明，头侧皮质杏仁核（CMA），特别是内侧核，是处理对雄性仓鼠交配行为至关重要的犁鼻和嗅觉刺激的重要部位。为了测试头侧内侧核损伤后出现的交配缺陷可能是由于对更多尾部区域的化学感觉传入的中断所致，将氚化氨基酸注射到在头侧CMA或基底外侧杏仁核中具有双侧电解损伤或假损伤的雄性仓鼠的副嗅球和主嗅球中，然后观察交配行为。对副嗅球的犁鼻投射和主嗅球的嗅觉投射进行放射自显影分析表明，头端 CMA 损伤损害了内侧核并延伸至大脑腹侧表面（腹侧损伤），中断了犁鼻对位于尾部的后内侧皮质核的输入，但保留了对杏仁核和梨状叶相邻尾部区域的嗅觉输入。相比之下，损伤内侧核的主要部分但保持其腹侧表面完整的病变（背侧病变）使犁鼻和嗅觉输入免受更多尾部区域的影响。背部和腹部均出现病变的动物术后无法交配；带有基底外侧杏仁核损伤的假损伤的动物，与背侧损伤一样，免受尾部定向的化学感觉传入，继续正常交配。头端 CMA 损伤后出现的交配缺陷主要是由于内侧核的破坏。
Previous studies suggest that the rostral corticomedial amygdala (CMA), particularly the medial nucleus, is an important site where vomeronasal and olfactory stimuli critical to male hamster copulatory behavior are processed. To test the possibility that mating deficits seen after lesions of the rostrally-placed medial nucleus may be due to the interruption of chemosensory afferents to more caudal areas, tritiated amino acids were injected into the accessory and main olfactory bulbs of male hamsters which had bilateral electrolytic lesions or sham lesions in either the rostral CMA or basolateral amygdala, and mating behavior was then observed. Autoradiographic analysis of vomeronasal projections from the accessory olfactory bulb and olfactory projections from the main bulb, revealed that rostral CMA lesions which damaged the medial nucleus and extended to the ventral surface of the brain (ventral lesions) interrupted vomeronasal input to the more caudally-placed posteromedial cortical nucleus, but spared olfactory inputs to adjacent caudal areas of the amygdala and piriform lobe. In contrast, lesions which damaged a major portion of the medial nucleus but left its ventral surface intact (dorsal lesions) spared both vomeronasal and olfactory inputs to more caudal areas. Animals with both dorsal and ventral lesions failed to mate postoperatively; animals bearing sham lesions of basolateral amygdaloid lesions, which, like dorsal lesions, spared caudally-directed chemosensory afferents, continued to mate normally. Mating deficits seen after rostral CMA lesions are due primarily to destruction of the medial nucleus.