Functions of Fascin in Dendritic Cells
Functions of Fascin in Dendritic Cells
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DOI：
10.1615/critrevimmunol.v32.i1.20
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发表时间：
2012-01-01
影响因子：
1.3
通讯作者：
Yamashiro, Shigeko
中科院分区：
文献类型：
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作者：
Yamashiro, Shigeko
Fasin-1是一种肌动蛋白捆绑蛋白，与其他肌动蛋白捆绑蛋白没有同源性。当树突状细胞(DC)成熟时，它被大量诱导。然而，在包括巨噬细胞和中性粒细胞在内的其他原代血细胞中不表达Fascin-1，这表明Fascin-1在DC成熟后的功能中具有独特的作用。越来越多的证据表明，Fascin-1在成熟相关的DC功能中发挥着关键作用，包括面纱样膜突起的动态组装、足体的解体、向淋巴结的迁移和免疫突触的组装。病理分析表明，Fasin-1是免疫细胞疾病的有用标记物，包括朗格汉斯细胞组织细胞增生症和霍奇金病。此外，由于Fascin-1启动子对DC具有很强的特异性，人们试图探索其在DNA疫苗中的应用。
Fascin-1 is an actin-bundling protein that shares no homology with other actin-bundling proteins. It is greatly induced upon maturation of dendritic cells (DCs). However, fascin-1 is not expressed in other primary blood cells, including macrophages and neutrophils, indicating a unique role of fascin-1 in the function of DCs upon maturation. An increasing body of evidence has shown that fascin-1 plays critical roles in maturation-associated DC functions, including dynamic assembly of veil-like membrane protrusions, disassembly of podosomes, migration to lymph nodes, and the assembly of the immunological synapse. Pathological analyses of fascin-1 expression revealed that fascin-1 is a useful marker of diseases of immune cells, including Langerhans cell histiocytosis and Hodgkin diseases. Furthermore, attempts have been made to explore the use of a fascin-1 promoter for DNA vaccination because it is strong and specific to DCs.