Regional volume changes of the brain in migraine chronification
Regional volume changes of the brain in migraine chronification
复制标题
偏头痛慢性化过程中大脑区域体积的变化
DOI：
10.4103/1673-5374.276360
复制
发表时间：
2020-09-01
影响因子：
6.1
通讯作者：
Yu, Sheng-Yuan
中科院分区：
文献类型：
--
作者：
Chen, Xiao-Yan;Chen, Zhi-Ye;Yu, Sheng-Yuan
偏头痛的病理生理学是复杂的。神经影像学研究揭示了偏头痛患者大脑的功能和结构变化。我们试图探讨发作性和慢性偏头痛患者颅内结构的区域体积差异。对16例发作性偏头痛患者、16例慢性偏头痛患者和24例正常对照者进行3.0T MRI扫描。142个脑区的体积通过自动体积算法计算，并与临床变量进行比较。结果表明，与对照组相比，发作性偏头痛患者的额叶和枕叶以及右侧壳核的特定区域的体积增加，而第四脑室的体积减少。慢性偏头痛患者的左侧基底前脑、视交叉和第四脑室体积减小，而枕叶皮质和右侧壳核体积增大。与发作性偏头痛患者相比，慢性偏头痛患者的左侧丘脑较大，额叶较小。相关分析显示头痛频率与右额极、右外侧眶回和内侧额叶的体积呈负相关，与左丘脑的体积呈正相关。睡眠障碍评分与左基底前脑体积呈负相关。这表明偏头痛患者在与疼痛处理和调制、情感和认知处理以及视觉感知相关的区域中存在结构变化。选择性颅内结构的重塑可能参与偏头痛发作。本研究于2018年5月31日获得中国人民解放军总医院伦理委员会批准（批件号：S2018-027-02）。
The pathophysiology of migraine is complex. Neuroimaging studies reveal functional and structural changes in the brains of migraine patients. We sought to explore regional volume differences in intracranial structures in patients with episodic and chronic migraine. Sixteen episodic migraine patients, 16 chronic migraine patients, and 24 normal controls were recruited and underwent 3.0 T MRI scanning. The volumes of 142 brain regions were calculated by an automatic volumetric algorithm and compared with clinical variables. Results demonstrated that the volumes of specific regions in the frontal and occipital lobes, and the right putamen, were increased and the volume of the fourth ventricle was decreased in the episodic migraine patients compared with controls. The volumes of the left basal forebrain, optic chiasm, and, the fourth ventricle were decreased in the chronic migraine patients, while the occipital cortex and the right putamen were larger. Compared to episodic migraine patiants, chronic migraine patients displayed larger left thalamus and smaller frontal regions. Correlation analysis showed that headache frequency was negatively correlated with the volume of the right frontal pole, right lateral orbital gyrus, and medial frontal lobes and positively correlated with the volume of the left thalamus. The sleep disturbance score was negatively correlated with the volume of the left basal forebrain. This suggests that migraine patients have structural changes in regions associated with pain processing and modulation, affective and cognitive processing, and visual perception. The remodeling of selective intracranial structures may be involved in migraine attacks. This study was approved by the Ethics Committee of Chinese PLA General Hospital (approval No. S2018-027-02) on May 31, 2018.