In the beginning is the end: regulation of poly(A) addition and removal during early development.
In the beginning is the end: regulation of poly(A) addition and removal during early development.
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开始即是结束：早期发育过程中 Poly(A) 添加和去除的调节。
DOI：
10.1016/0968-0004(90)90022-4
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发表时间：
1990
影响因子：
13.8
通讯作者：
Wickens,M
中科院分区：
文献类型：
--
作者：
Wickens,M
多聚(A)尾在细胞核内几乎所有mrna上的添加在7月号的tibs1上进行了综述。在这里，我们将焦点转移到poly(A)尾巴在早期发育过程中的命运。在卵子发生和胚胎发生的特定时期，某些母体mrna的多聚(A)尾部被延长，而其他一些mrna的尾部被去除。选择性多聚(A)加成反应受3'非翻译区短的富u序列调控，而从特定mrna中去除多聚(A)是一种“默认状态”，不需要特定的序列。这些poly(A)长度的调控变化可能在卵子和早期胚胎的翻译调控中发挥重要作用。
The addition of poly(A) tails to nearly all mRNAs within the nucleus was reviewed in the July issue ofTIBS1. Here we shift focus to the fate of poly(A) tails during early development. At specific times during oogenesis and embryogenesis, the poly(A) tails of certain maternal mRNAs are lengthened, while the tails of a number of other mRNAs are removed. The selective poly(A) addition reactions are regulated by a short, U-rich sequence in the 3' untranslated region, while the removal of poly(A) from specific mRNAs is a ‘default state’, requiring no specific sequence. These regulated changes in poly(A) length are likely to play a major role in translational regulation in the egg and early embryo.