Intergenerational transmission of childhood conduct problems - A children of twins study
Intergenerational transmission of childhood conduct problems - A children of twins study
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DOI：
10.1001/archpsyc.64.7.820
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发表时间：
2007-07-01
影响因子：
--
通讯作者：
Martin, Nicholas G.
中科院分区：
文献类型：
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作者：
D'Onofrio, Brian M.;Slutske, Wendy S.;Martin, Nicholas G.
内容：儿童期行为问题的家族性已经有了很好的文献记载，但很少有遗传学方面的研究明确探讨了父母行为问题影响后代行为问题的过程。目的：描述儿童期行为问题代际传递的遗传和环境过程。设计：我们使用分层线性模型来分析来自双胞胎研究的数据，这是一项准实验设计，旨在探索两代人共有的遗传因素，双胞胎共有的未测量的环境因素，背景：参与者从社区招募并完成半结构化诊断电话访谈。参与者：这项研究使用了来自澳大利亚双胞胎登记处的889个双胞胎家庭的高风险双胞胎，他们的配偶和他们的年轻成年后代（n= 2554），结果：行为障碍症状的代际传递对所有后代都有显著性意义，但对男性的影响更大（效应量[Cohen d]= 0.21; 95%置信区间，0.15-0.17）比女性（d= 0.09; 95%置信区间，0.05-0.14）。使用双胞胎的设计和测量的协变量表明，代际传递的行为问题的男性后代主要是介导的环境变量，特别是与父母的行为障碍（d= 0.13，95%的置信区间，0.02-0.23）。相反，行为问题的代际传递，是不是因为环境介导的因果过程为女性后代（d=-0.09，95%置信区间，-0.20至0.03）;一个共同的遗传责任占代际relationships.Conclusions：行为问题的代际传递的机制取决于后代的性别。结果是一致的环境介导的因果关系的作用，父母的行为问题，在男性的行为问题。然而，常见的遗传风险会混淆女性后代的整个代际传递。
Context: The familial nature of childhood conduct problems has been well documented, but few genetically informed studies have explicitly explored the processes through which parental conduct problems influence an offspring's behavior problems.Objective: To delineate the genetic and environmental processes underlying the intergenerational transmission of childhood conduct problems.Design: We used hierarchical linear models to analyze data from a Children of Twins Study, a quasiexperimental design, to explore the extent to which genetic factors common to both generations, unmeasured environmental factors that are shared by twins, or measured characteristics of both parents confound the intergenerational association.Setting: Participants were recruited from the community and completed a semistructured diagnostic telephone interview.Participants: The research used a high-risk sample of twins, their spouses, and their young adult offspring ()n= 2554) from 889 twin families in the Australian Twin Registry, but the analyses used sample weights to produce parameter estimates for the community-based volunteer sample of twins.Main Outcome Measure: Number of conduct disorder symptoms.Results: The magnitude of the intergenerational transmission was significant for all offspring, though it was stronger for males (effect size [Cohen d]= 0.21; 95% confidence interval, 0.15-0.17) than females (d= 0.09; 95% confidence interval, 0.05-0.14). The use of the Children of Twins design and measured covariates indicated that the intergenerational transmission of conduct problems for male offspring was largely mediated by environmental variables specifically related to parental conduct disorder (d= 0.13; 95% confidence interval, 0.02-0.23). In contrast, the intergenerational transmission of conduct problems was not because of environmentally mediated causal processes for female offspring (d=-0.09; 95% confidence interval, -0.20 to 0.03); a common genetic liability accounted for the intergenerational relations.Conclusions: The mechanisms underlying the intergenerational transmission of conduct problems depend on the sex of the offspring. The results are consistent with an environmentally mediated causal role of parental conduct problems on behavior problems in males. Common genetic risk, however, confounds the entire intergenerational transmission in female offspring.