mecA is not involved in the σB-dependent switch of the expression phenotype of methicillin resistance in Staphylococcus epidermidis
mecA is not involved in the σB-dependent switch of the expression phenotype of methicillin resistance in Staphylococcus epidermidis
复制标题
DOI：
10.1128/aac.49.3.1216-1219.2005
复制
发表时间：
2005-03-01
影响因子：
4.9
通讯作者：
Mack, D
中科院分区：
文献类型：
--
作者：
Knobloch, JKM;Jäger, S;Mack, D
缺乏sigma(B)活性降低了异质性表皮葡萄球菌1057的甲氧西林抗性，而抗sigma因子RsbW失活将表型转换为均匀的抗性表达。在sigma(B)阴性菌株中，Oxacillin诱导的mecA转录减少。然而，mecA不参与表达表型的转换。
A lack of sigma(B) activity reduces methicillin resistance in heterogeneous Staphylococcus epidermidis 1057, whereas inactivation of the anti-sigma factor RsbW switched the phenotype to homogeneous expression of resistance. Oxacillin induction of mecA transcription is reduced in a sigma(B)-negative strain. However, mecA is not involved in the switch of expression phenotype.