miR-370-3p Is a Therapeutic Tool in Anti-glioblastoma Therapy but Is Not an Intratumoral or Cell-free Circulating Biomarker.
miR-370-3p Is a Therapeutic Tool in Anti-glioblastoma Therapy but Is Not an Intratumoral or Cell-free Circulating Biomarker.
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DOI：
10.1016/j.omtn.2018.09.007
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发表时间：
2018-12-07
期刊：
影响因子：
--
通讯作者：
Cartron PF
中科院分区：
文献类型：
--
作者：
Nadaradjane A;Briand J;Bougras-Cartron G;Disdero V;Vallette FM;Frenel JS;Cartron PF
在过去的十年中，microRNAs（miRs）已被描述为生物标志物和治疗剂。基于这一发现，我们的目的是了解（1）miRNA-370- 3 p是否可以用作与良好生存相关的生物标志物，以及（2）miRNA-370- 3 p是否可以用作提高标准抗GBM治疗效率的治疗工具。使用“预后miRNA数据库”上可用的数据的第一种方法表明，GBM中miRNA-370- 3 p（T-miR-370- 3 p）的表达水平与存活的预后值无关。定量无细胞循环miRNA-370- 3 p（cfc-miR-370- 3 p）的表达水平的第二种方法也表明cfc-miR-370- 3 p与存活的预后值无关。为了研究miR-370- 3 p是否可以在体内用于增加TMZ的抗GBM作用，我们随后在小鼠中使用LN 18诱导的GBM模型。我们的数据表明，miRNA-370- 3 p/TMZ治疗在减小肿瘤体积方面比TMZ治疗有效两倍。此外，我们的研究将miRNA-370- 3 p/TMZ治疗诱导的肿瘤体积减少与FOXM 1和MGMT的减少相关（即，miR-370- 3 p的两个靶点）。因此，我们的数据支持miR-370- 3 p可以用作抗胶质母细胞瘤治疗的治疗工具，但不能用作生物标志物的想法。
In the last decade, microRNAs (miRs) have been described as biomarkers and therapeutic agents. Based on this finding, our aim here is to know if (1) miRNA-370-3p can be used as a biomarker associated with a favorable survival and if (2) miRNA-370-3p can be used as a therapeutic tool that increases the efficiency of standard anti-GBM treatment. A first approach using the data available on the “Prognostic miRNA Database” indicated that the expression level of miRNA-370-3p in GBM (T-miR-370-3p) is not associated with a prognosis value for survival. A second approach quantifying the expression level of cell-free circulating miRNA-370-3p (cfc-miR-370-3p) also indicated that cfc-miR-370-3p is not associated with a prognosis value for survival. To investigate whether miR-370-3p can be used in vivo to increase the anti-GBM effect of TMZ, we then used the model of LN18-induced GBMs in mice. Our data indicated that the miRNA-370-3p/TMZ treatment was two times more efficient than the TMZ treatment for decreasing the tumor volume. In addition, our study correlated the decrease of tumor volume induced by the miRNA-370-3p/TMZ treatment with the decrease in FOXM1 and MGMT (i.e., two targets of miR-370-3p). Our data thus support the idea that miR-370-3p could be used as therapeutic tool for anti-glioblastoma therapy, but not as a biomarker.
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