Vascular remodeling after laser photocoagulation: concurrent regeneration and atrophy.
Vascular remodeling after laser photocoagulation: concurrent regeneration and atrophy.
复制标题
激光光凝后的血管重塑：同时再生和萎缩。
DOI：
10.1159/000147241
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
G. Korte
中科院分区：
文献类型：
--
作者：
A. Pollack;G. Korte
激光光凝会带来矛盾的结果：它会导致血管消失，但也会导致新血管的形成。为了更好地理解这种双重血管反应，我们对大鼠氪激光损伤后脉络膜血管修复进行了超微结构研究。观察到三个过程：再通、新血管形成以及再通和新形成的毛细血管的萎缩。因此，脉络膜血管系统的激光修复可以被描述为重塑过程，其特征是再生和复旧。后者似乎是继发性萎缩过程，导致永久性血管闭塞。这些机制可能解释了为什么尽管最初有血管再生，激光光凝治疗对脉络膜视网膜下新生血管形成仍具有有益作用。
Laser photocoagulation is associated with paradoxical results: it causes obliteration of vessels, but leads also to the formation of new ones. In an attempt to better understand this dual vascular response we conducted an ultrastructure study of the choroidal vascular repair following krypton laser injury in rats. Three processes were observed: recanalization, neovascularization, and atrophy of both recanalized and newly formed capillaries. Post-lasering repair of the choroidal vasculature can therefore be described as a remodeling process, characterized by both regeneration and involution. The latter appears to be a secondary process of atrophy, contributing to permanent vascular obliteration. These mechanisms might explain why, in spite of initial vascular regeneration, laser photocoagulation treatment has a beneficial effect on choroidal subretinal neovascularization.