Effect of urbanisation on the relationship between total serum IgE and asthma.
Effect of urbanisation on the relationship between total serum IgE and asthma.
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DOI：
10.1183/09031936.00025512
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
PURA study investigators
中科院分区：
文献类型：
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作者：
Checkley W;Robinson CL;Baumann LM;Romero K;Combe JM;Gilman RH;Wise RA;Hamilton RG;Gonzalvez G;Cama V;Hansel NN;PURA study investigators
目前尚不清楚血清总IgE与哮喘的关系是否随城市化程度的不同而不同。我们假设，血清总IgE与哮喘的关系在城市环境中比在农村环境中更明显。我们在秘鲁利马的一个城市周边棚户区(n=725)和秘鲁农村的23个村庄(n=716)招募了1441名年龄在13-15岁的儿童。我们询问了参与者哮喘和过敏症状、环境暴露和社会人口学；并进行了肺活量测定、呼出一氧化氮和过敏皮肤测试。我们采集了1143名(79%)参与者的血清总IgE。利马地区血清总免疫球蛋白E几何均数高于汤姆贝斯地区(262vs192kU·L−1；p<；0.001)。在利马和汤姆贝斯，每增加一个对数单位的血清，患哮喘的几率分别增加1.6倍(95%可信区间1.3-2.0)和1.4倍(95%可信区间0.9-2.1)。特应性是血清总IgE与哮喘关系的效应修饰者。在特应性患者和非特应性患者中，血清总IgE每增加一个对数单位，哮喘的风险分别增加2.0倍(95%可信区间1.5~2.7)和1.0倍(95%可信区间0.7~1.4)。血清总IgE与特应性哮喘相关，但与非特应性哮喘无关。城市化似乎并不是这种关系的效果修饰符。
It is unclear if the relationship of total serum IgE with asthma varies with degree of urbanisation. We hypothesised that the relationship of total serum IgE to asthma is more pronounced in an urban versus a rural environment. We enrolled 1441 children aged 13–15 years in a peri-urban shanty town in Lima, Peru (n=725) and 23 villages in rural Tumbes, Peru (n=716). We asked participants about asthma and allergy symptoms, environmental exposures and sociodemographics; and performed spirometry, and exhaled nitric oxide and allergy skin testing. We obtained blood for total serum IgE in 1143 (79%) participants. Geometric means for total serum IgE were higher in Lima versus Tumbes (262 versus 192 kU·L−1; p<0.001). The odds of asthma increased by factors of 1.6 (95% CI 1.3–2.0) versus 1.4 (95% CI 0.9–2.1) per log unit increase in total serum in Lima versus Tumbes, respectively. Atopy was an effect modifier of the relationship of total serum IgE on asthma. Among atopics and non-atopics, the odds of asthma increased by a factor of 2.0 (95% CI 1.5–2.7) and 1.0 (95% CI 0.7–1.4) per log unit increase in total serum IgE, respectively. Total serum IgE was associated with atopic asthma but not with non-atopic asthma. Urbanisation did not appear to be an effect modifier of this relationship.