HSV-induced apoptosis in herpes encephalitis.
HSV-induced apoptosis in herpes encephalitis.
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DOI：
10.1007/3-540-27320-4_4
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发表时间：
2005
影响因子：
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通讯作者：
L. Aurelian
中科院分区：
文献类型：
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作者：
L. Aurelian
HSV以细胞类型特异性的方式触发和阻止细胞凋亡。这篇综述讨论了目前对细胞凋亡和信号级联在神经元发病和存活中的作用的理解，并总结了HSV感染对这些严格平衡过程的调节的最新发现。值得强调的是，在成人受试者中，HSV-1而非HSV-2可引发中枢神经系统神经元凋亡并引起脑炎。本文描述了两种HSV血清型感染不同结果的机制，包括病毒抗凋亡基因的作用，特别是HSV-2基因ICP10PK。讨论了HSV载体在未来治疗发展中的潜在应用。
HSV triggers and blocks apoptosis in cell type-specific fashion. This review discusses present understanding of the role of apoptosis and signaling cascades in neuronal pathogenesis and survival and summarizes present findings relating to the modulation of these strictly balanced processes by HSV infection. Underscored are the findings that HSV-1, but not HSV-2, triggers apoptosis in CNS neurons and causes encephalitis in adult subjects. Mechanisms responsible for the different outcomes of infection with the two HSV serotypes are described, including the contribution of viral antiapoptotic genes, notably the HSV-2 gene ICP10PK. Implications for the potential use of HSV vectors in future therapeutic developments are discussed.