Improved target volume characterization in stereotactic treatment planning of brain lesions by using high‐resolution BOLD MR‐venography
Improved target volume characterization in stereotactic treatment planning of brain lesions by using high‐resolution BOLD MR‐venography
复制标题
使用高分辨率 BOLD MR 静脉造影改善脑部病变立体定向治疗计划中的靶体积表征
作者：
L. Schad
在这篇方法学论文中，我报告了不同磁共振成像（MRI）技术[MR血管造影（MRA）、MRI、血团标记（星星）、功能性MRI和高分辨率BOLD静脉造影（HRBV）]在脑动静脉畸形（AVM）和脑肿瘤患者中的立体定向相关性。将患者头部固定在立体定向定位系统中，该系统可用于MR系统和直线加速器装置。使用体模测量，可以通过基于将失真建模为四阶二维多项式的计算来"校正"全局几何MR图像失真（将位移减少到像素的大小）。进一步的物体引起的局部失真可以通过额外测量的场图来校正。使用这种方法，多模态匹配可以自动执行，只要所有图像都是在同一检查中采集的，并且患者被充分固定以允许精确定义目标体积。AVM的血流动力学信息由采用星星技术的动态MRA提供，改善了病灶大小、供血动脉起源的定义，而HRBV成像提供了有关静脉模式和引流的详细和改善的信息。此外，在病变靠近初级运动皮质区的患者中进行了功能性MRI，从而改善了放射外科高剂量应用风险结构的定义。在脑肿瘤患者中，HRBV探测肿瘤血管生成的潜力及其在调强治疗计划中的应用仍然受到如何将肿瘤中测量的BOLD信号模式转化为剂量分布的开放性问题的阻碍，这应该在未来的研究中解决。版权所有© 2001约翰威利父子有限公司。
In this methodological paper I report the stereotactic correlation of different magnetic resonance imaging (MRI) techniques [MR angiography (MRA), MRI, blood bolus tagging (STAR), functional MRI, and high‐resolution BOLD venography (HRBV)] in patients with cerebral arterio‐venous malformations (AVM) and brain tumors. The patient's head was fixed in a stereotactic localization system which is usable in both MR‐systems and linear accelerator installations. Using phantom measurements global geometric MR image distortions can be ‘corrected’ (reducing displacements to the size of a pixel) by calculations based on modeling the distortion as a fourth‐order two‐dimensional polynomial. Further object‐induced local distortions can be corrected by additionally measured field maps. Using this method multimodality matching could be performed automatically as long as all images are acquired in the same examination and the patient is sufficiently immobilized to allow precise definition of the target volume. Information about the hemodynamics of the AVM was provided by a dynamic MRA with the STAR technique, leading to an improved definition of the size of the nidus, the origin of the feeding arteries, whereas HRBV imaging yielded detailed and improved information about the venous pattern and drainage. In addition, functional MRI was performed in patients with lesions close to the primary motor cortex area, leading to an improved definition of structures at risk for the high‐dose application in radiosurgery. In patients with brain tumors the potential of HRBV to probe tumor angiogenesis and its use in intensity‐modulated treatment planning is still hampered by the open question of how to translate a BOLD signal pattern measured in the tumor to a dose distribution, which should be addressed in future studies. Copyright © 2001 John Wiley & Sons, Ltd.
调制场三维适形放射治疗的实现与验证。
DOI：
10.1016/0360-3016(94)90366-2
发表时间：
1994
期刊：
International journal of radiation oncology, biology, physics
影响因子：
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作者：
Bortfeld,T;Boyer,AL;Schlegel,W;Kahler,DL;Waldron,TJ
通讯作者：
Waldron,TJ