Meat, fat, and their subtypes as risk factors for colorectal cancer in a prospective cohort of women
Meat, fat, and their subtypes as risk factors for colorectal cancer in a prospective cohort of women
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DOI：
10.1093/aje/kwg099
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发表时间：
2003-07-01
影响因子：
5
通讯作者：
Schatzkin, A
中科院分区：
文献类型：
--
作者：
Flood, A;Velie, EM;Schatzkin, A
作者在美国一个前瞻性的女性队列中调查了肉类和脂肪摄入量与结直肠癌的关系。在1987年至1989年期间，45，496名妇女完成了62项国家癌症研究所/块状食物频率问卷，在386，716人年的随访期间，有487例结肠直肠癌病例。作者使用考克斯比例风险回归来估计总肉、红肉、白色肉、加工肉和全熟肉摄入量以及总脂肪、饱和脂肪和不饱和脂肪的相对风险和95%置信区间。总肉类和红肉消费量增加五分位数的相对风险表明红肉与结直肠癌无关（高与低五分位数相比的相对风险= 1.10，95%置信区间：0.83，1.45）。对于总脂肪，也没有增加五分位数的消费（高与低五分位数相比的相对风险= 1.14，95%置信区间：0.86，1.53）。此外，肉类或脂肪的其他亚型都没有显示出与结直肠癌的任何关联。这项研究没有证据表明肉类或脂肪（或其任何亚型）与结直肠癌发病率之间存在关联，但作者不能排除适度关联的可能性。
The authors investigated the association of intakes of meat and fat with colorectal cancer in a prospective cohort of women in the United States. Between 1987 and 1989, 45,496 women completed a 62-item National Cancer Institute/Block food frequency questionnaire, and during 386,716 person-years of follow-up, there were 487 incident cases of colorectal cancer. The authors used Cox proportional hazards regression to estimate relative risks and 95% confidence intervals for total meat, red meat, white meat, processed meat, and well-done meat intakes, as well as for total fat, saturated fat, and unsaturated fat. Relative risks for increasing quintiles of total meat and red meat consumption indicated no association with colorectal cancer (relative risk for high compared with low quintile = 1.10, 95% confidence interval: 0.83, 1.45) for red meat. For total fat, there was also no association with increasing quintiles of consumption (relative risk for high compared with low quintile = 1.14, 95% confidence interval: 0.86, 1.53). Additionally, none of the other subtypes of either meat or fat showed any association with colorectal cancer. This study provided no evidence of an association between either meat or fat (or any of their subtypes) and colorectal cancer incidence, but the authors cannot rule out the possibility of a modest association.