Relation of positive L.E.-cell preparations to activity of lupus erythematosus and corticosteroid therapy.
Relation of positive L.E.-cell preparations to activity of lupus erythematosus and corticosteroid therapy.
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阳性 L.E. 细胞制剂与红斑狼疮活动和皮质类固醇治疗的关系。
DOI：
10.1056/nejm196203152661103
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发表时间：
1962
期刊：
影响因子：
--
通讯作者：
N. Pace
中科院分区：
文献类型：
--
作者：
N. Rothfield;N. Pace
在引入皮质类固醇疗法治疗系统性红斑狼疮后，文献中出现了关于新药对 L.E. 细胞现象的影响的相互矛盾的报告。大多数调查人员一致认为 L.E.与病情缓解或病情较轻的患者相比，在急性疾病患者中更频繁地发现细胞。1 2 3 4 一些人报告说，L.E.类固醇治疗后不再发现细胞，3 , 5 6 7 8 9 以及其他人认为类固醇治疗后细胞仍然存在。 10 , 11 经过十年的经验，重新评估了类固醇对 L.E 的影响。细胞和疾病活动与的关系。 。 。
AFTER the introduction of corticosteroid therapy for systemic lupus erythematosus, conflicting reports on the effect of the new agents on the L.E.-cell phenomenon appeared in the literature. Most investigators agreed that L.E. cells were found more frequently in acutely ill patients than in those who were in remission or whose disease was milder.1 2 3 4 Some reported that L.E. cells could no longer be found after steroid therapy,3 , 5 6 7 8 9 and others that the cells persisted after steroid therapy.10 , 11 After a decade of experience a reappraisal of the effects of steroids on the L.E. cell and of the relation of disease activity to the . . .