Developing new metal-based therapeutics: challenges and opportunities
Developing new metal-based therapeutics: challenges and opportunities
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DOI：
10.1039/b706075k
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发表时间：
2007-01-01
影响因子：
4
通讯作者：
Hambley, Trevor W.
中科院分区：
文献类型：
--
作者：
Hambley, Trevor W.
临床试验中遇到的意想不到的副作用和问题给那些开发新药的人造成了困难的环境，因此，正在注册的新化学实体的数量降至历史低点。那些开发基于金属的疗法的人将面临同样的困难，但这种环境也为应用创造性的解决方案来克服这些问题和担忧提供了许多机会。从这个角度来看，这些挑战和机会是在一些基于金属的治疗方法的例子的背景下被考虑的。
Unexpected side effects and problems experienced in clinical trials have created a difficult environment for those developing new pharmaceuticals and, as a consequence, the number of new chemical entities being registered has fallen to a historic low. Those developing metal-based therapeutics will face the same difficulties, but this environment also provides many opportunities for creative solutions to be applied to overcoming the problems and concerns. In this perspective, these challenges and opportunities are considered in the context of examples of a number of classes of metal-based therapeutics.