Quantitative regulation of histone variant H2A.Z during cell cycle by ubiquitin proteasome system and SUMO-targeted ubiquitin ligases
Quantitative regulation of histone variant H2A.Z during cell cycle by ubiquitin proteasome system and SUMO-targeted ubiquitin ligases
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泛素蛋白酶体系统和 SUMO 靶向泛素连接酶对细胞周期中组蛋白变体 H2A.Z 的定量调节
DOI：
10.1080/09168451.2017.1326087
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Harata Masahiko
中科院分区：
文献类型：
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作者：
Takahashi Daisuke;Orihara Yuki;Kitagawa Saho;Kusakabe Masayuki;Shintani Takahiro;Oma Yukako;Harata Masahiko
组蛋白和组蛋白变体在细胞周期中的定量控制与它们的表观遗传功能有关。我们发现，通过泛素蛋白酶体系统和相扑靶向的泛素连接酶，在G2/M期酵母组蛋白变异体H2A.Z的水平被积极地保持在较低的水平。H_2A.Z的过表达导致有丝分裂进程中的缺陷，表明这种定量控制的功能重要性。
Quantitative control of histones and histone variants during cell cycle is relevant to their epigenetic functions. We found that the level of yeast histone variant H2A.Z in the G2/M-phase is actively kept low by the ubiquitin proteasome system and SUMO-targeted ubiquitin ligases. Overexpression of H2A.Z induced defects in mitotic progression, suggesting functional importance of this quantitative control.