INFLUENCE OF HEPATITIS-DELTA-VIRUS INFECTION ON PROGRESSION TO CIRRHOSIS IN CHRONIC HEPATITIS TYPE-B
INFLUENCE OF HEPATITIS-DELTA-VIRUS INFECTION ON PROGRESSION TO CIRRHOSIS IN CHRONIC HEPATITIS TYPE-B
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DOI：
10.1093/infdis/155.5.931
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发表时间：
1987-05-01
影响因子：
6.4
通讯作者：
REALDI, G
中科院分区：
文献类型：
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作者：
FATTOVICH, G;BOSCARO, S;REALDI, G
在连续146例慢性乙型肝炎患者中，有18例（12%）发现丁型肝炎病毒（HDV）感染的血清学标志物，并分析了HDV抗体（抗HDV阳性）患者的特征。在 1 至 15 年的随访期间，77% 的抗 HDV 阳性患者的组织学恶化；然而，在未感染 HDV 的乙型肝炎表面抗原 (HBsAg) 携带者中，30% 的患者组织学恶化，但大多数患者的组织学状况有所改善或保持不变 (P < .01)。在 10 名抗 HDV 阳性患者中，有 7 名 (70%) 表现出从慢性活动性肝炎转变为肝硬化，这一事件是在随访的头两年内观察到的。抗 HDV 阳性患者发展为肝硬化的概率显着高于无 HDV 抗体的患者（P
Serological markers of hepatitis delta virus (HDV) infection were found in 18 (12%) of 146 consecutive patients with chronic hepatitis B, and the characteristics of patients who had antibody to HDV (anti-HDV-positive) were analyzed. During one to 15 years of follow-up, histological deterioration was documented in 77% of anti-HDV-positive patients; however, in hepatitis B surface antigen (HBsAg) carriers without HDV infection, histology deteriorated in 30% but improved or remained unchanged in the majority of patients (P < .01). In seven (70%) of the 10 anti-HDV-positive patients who showed transition from chronic active hepatitis to cirrhosis, this event was observed within the first two years of follow-up. The probability of evolution to cirrhosis was significantly higher in anti-HDV-positive patients than in patients without antibody to HDV (P