Carbonic anhydrase I and II autoantibodies in Behçet's disease.
Carbonic anhydrase I and II autoantibodies in Behçet's disease.
复制标题
白塞病中的碳酸酐酶 I 和 II 自身抗体。
DOI：
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
I. Turan
中科院分区：
文献类型：
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作者：
A. Menteşe;A. Alver;S. Demir;A. Sumer;Serap Ozer Yaman;M. Karkucak;Arzu Aydin Çapkin;Diler Us Altay;I. Turan
背景
BEHçet‘s病是一种血管炎，在地中海和远东地区更常见，表现为口腔和生殖器溃疡、皮肤损害和葡萄膜炎。碳酸酐酶(CA)是一种广泛存在于生物体中的金属酶，对调节酸碱平衡起着至关重要的作用。抗CA抗体在许多疾病中都有报道，如系统性红斑狼疮、干燥综合征、类风湿性关节炎、子宫内膜异位症、特发性慢性胰腺炎、1型糖尿病和Graves病。这项研究的目的是研究白塞病(BD)中的CA I和II自身抗体。
方法
采用双抗体夹心法检测35例BD患者和29例健康人血清中CA I、II自身抗体水平。
结果
BD组CA I、II自身抗体水平显著高于健康组(P=0.013，P=0.0001)。以0.250 ABSU为界值预测BD的敏感度为34%，特异度为100%；以0.171 ABSU为界值预测BD的敏感度为54%，特异度为100%。
结论
BD患者血清中CA I、II自身抗体水平明显高于对照组，提示CA I、II自身抗体可能参与了BD的发病机制。
BACKGROUND
Behçet's disease is a vasculitis, seen more frequently around the Mediterranean and the Far East, and evinces with oral and genital ulcerations, skin lesions and uveitis. Carbonic anhydrase (CA) is a metalloenzyme which is widely distributed in the living world, and it is essential for the regulation of acid-base balance. Anti-CA antibodies have been reported in many disorders, such as systemic lupus erythematosus, Sjögren's syndrome, rheumatoid arthritis, endometriosis, idiopathic chronic pancreatitis, type 1 diabetes and Graves' disease. The goal of this study was to investigate CA I and II autoantibodies in Behçet's disease (BD).
METHODS
35 patients with BD and 29 healthy controls were included in the study and CA I and II autoantibody levels were investigated by ELISA.
RESULTS
The CA I and II autoantibody levels of BD group were significantly higher than the healthy group (p=0.013, p inf 0.0001, respectively). A cut-off value of 0.250 ABSU for anti-CA I was associated with 34 % sensitivity and 100 % specificity and a cut-off value of 0.171 ABSU for anti-CA II was associated with 54 % sensitivity and 100 % specificity for predicting BD.
CONCLUSION
The CA I and II autoantibody levels in patients with BD were found higher compared to control group and the results suggest that CA I and II autoantibodies may be involved in the pathogenesis of BD.