Resorbable implants in trauma surgery
Resorbable implants in trauma surgery
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DOI：
10.1007/s41970-018-0041-6
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发表时间：
2018-10-01
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影响因子：
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通讯作者：
Weinberg, Annelie-Martina
中科院分区：
文献类型：
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作者：
Grun, Nicole Gabriele;Donohue, Nicholas;Weinberg, Annelie-Martina
生物可吸收植入物是目前骨科和创伤外科的主要目标之一。优点是显而易见的：不需要进行潜在困难的植入物移除手术，从而避免并发症。越来越多的患者对植入物表现出金属敏感性，其长期后果仍有待确定。此外，还有一个道德要求，每个人都应该完好无损地进入老年，并在受伤后完全恢复。因此，PLLA/PLGA等可吸收植入物被更频繁地使用，尽管它们的脆性使其不适合用于承载骨折稳定。复合材料和生物陶瓷面临着类似的问题。所有这些合成骨替代品都具有高度的生物相容性，但仅适用于非承重区域。长期以来，镁植入物一直是一种替代方案，尽管到目前为止，它们的缺点是无法充分控制降解，并且在降解过程中产生凹坑腐蚀导致气体形成。尽管会产生这种气体，但研究表明，由于镁具有优异的、经证实的骨诱导作用，因此具有非常高的完全愈合率。由于这些特性，镁也可以用于生产病理骨条件的植入物。
Bioresorbable implants are currently one of the main goals in orthopedic and trauma surgery. The advantages are apparent: potentially difficult implant removal operations are unnecessary, thereby avoiding complications. A growing number of patients exhibit metal sensitivity to implants, the long-term consequences of which remain to be determined. Additionally, there is an ethical requirement, that every person should reach old age undamaged and be completely restored following injury.As a result, resorbable implants such as PLLA/PLGA are being used more frequently, although their brittleness makes them unsuitable for load-bearing fracture stabilization. Composites and bioceramics face similar problems. All of these synthetic bone substitutes are highly biocompatible, but only suitable for use in nonload-bearing regions. Magnesium implants have been an alternative for a long time, although until now, they had the disadvantage that degradation could not be controlled sufficiently and the resulting pit corrosion lead to gas formation during degradation. Despite this gas formation, studies have shown a very high, complete healing rate, which is caused by the excellent, proven osteoinduction of magnesium. Due to these properties, magnesium can also be used for the production of implants for pathological bone conditions.