A versatile all-channel stimulator for electrode arrays, with real-time control.
A versatile all-channel stimulator for electrode arrays, with real-time control.
复制标题
用于电极阵列的多功能全通道刺激器，具有实时控制功能。
DOI：
10.1088/1741-2560/1/1/006
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发表时间：
2004
影响因子：
4
通讯作者：
Potter,SteveM
中科院分区：
文献类型：
--
作者：
Wagenaar,DanielA;Potter,SteveM
在过去的几十年里，通过越来越多的电极进行记录的技术已经为电生理学家所掌握。然而，对于分布式神经处理的研究，通过相等数量的电极进行刺激的能力，从而实现双向通信，是至关重要的。在这里，我们提出了一个多电极阵列的刺激系统，它与现有的商业记录硬件接口，并允许通过阵列中的任何电极刺激，通道之间的快速切换。该系统通过实时Linux进行控制，因此非常灵活：可以即时构建刺激序列，如果需要，可以使用任意刺激波形。这种设计的一个关键特点是，它可以很容易地和廉价地复制在其他实验室，因为它接口到标准的PC并行端口，只使用现成的组件。此外，与体内多电极探针一起使用的适配将是直接的。与我们免费提供的数据采集软件MeaBench相结合，该系统可以在15 ms内响应记录的动作电位提供反馈刺激。
Over the last few decades, technology to record through ever increasing numbers of electrodes has become available to electrophysiologists. For the study of distributed neural processing, however, the ability to stimulate through equal numbers of electrodes, and thus to attain bidirectional communication, is of paramount importance. Here, we present a stimulation system for multi-electrode arrays which interfaces with existing commercial recording hardware, and allows stimulation through any electrode in the array, with rapid switching between channels. The system is controlled through real-time Linux, making it extremely flexible: stimulation sequences can be constructed on-the-fly, and arbitrary stimulus waveforms can be used if desired. A key feature of this design is that it can be readily and inexpensively reproduced in other labs, since it interfaces to standard PC parallel ports and uses only off-the-shelf components. Moreover, adaptation for use with in vivo multi-electrode probes would be straightforward. In combination with our freely available data-acquisition software, MeaBench, this system can provide feedback stimulation in response to recorded action potentials within 15 ms.