MRI atrophy of the caudate nucleus and slower walking speed in the elderly
MRI atrophy of the caudate nucleus and slower walking speed in the elderly
复制标题
DOI：
10.1016/j.neuroimage.2012.01.102
复制
发表时间：
2012-04-02
期刊：
影响因子：
5.7
通讯作者：
Elbaz, Alexis
中科院分区：
文献类型：
--
作者：
Dumurgier, Julien;Crivello, Fabrice;Elbaz, Alexis
脑白质损伤与老年人较差的运动能力有关，但灰质萎缩的作用在很大程度上仍不清楚。我们在3C-Dijon研究中调查了大脑区域灰质体积与步行速度之间的横截面关系，该研究是一项基于人群的大型研究，研究对象为65岁及以上的社区居民(N=1623)。使用自动解剖标记分割方法获得局部灰质体积。采用半贝叶斯方法进行多变量分析。在调整了潜在的混杂因素后，行走较慢的人的基底节体积较小(回归系数[β]=0.054。标准差[SE]=0.028，p=0.05)。在更详细的分析中，尾状核的体积在这种联系中起着主导作用(β=0.049，SE=0.019，p=0.009)，行走速度随着尾状核的体积而递减(p为线性趋势
Cerebral white matter lesions are associated with poorer motor performances in the elderly, but the role of gray matter atrophy remains largely unknown. We investigated the cross-sectional relation between brain regional gray matter volumes and walking speed over 6 m in the 3C-Dijon study, a large population-based study of community-dwelling persons aged 65 years and over (N=1623). Regional gray matter volumes were obtained using an automated anatomical labeling parcellation method. Multivariable analyses were performed using a semi-Bayes approach. After adjustment for potential confounders, persons who walked slower had a smaller volume of basal ganglia (regression coefficient [beta] = 0.054. standard error [SE] = 0.028, p = 0.05). In more detailed analyses, the volume of the caudate nucleus had a preponderant role on this association (beta = 0.049, SE = 0.019, p = 0.009), and walking speed decreased progressively with the volume of the caudate nucleus (p for linear trend