Depletion of CD4(+) or CD8(+) T-cells prevents Plasmodium berghei induced cerebral malaria in end-stage disease
Depletion of CD4(+) or CD8(+) T-cells prevents Plasmodium berghei induced cerebral malaria in end-stage disease
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DOI：
10.1017/s0031182096008293
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发表时间：
1997-01-01
期刊：
影响因子：
2.4
通讯作者：
Eling, W
中科院分区：
文献类型：
--
作者：
Hermsen, C;VandeWiel, T;Eling, W
用抗CD 4或抗CD 8单克隆抗体治疗感染伯氏疟原虫K173或伯氏疟原虫ANKA的C57 B1/6 J和C57 B1/10小鼠，分析T细胞在实验性脑型疟疾发展中的作用。在感染前或感染期间注射抗CD 4或抗CD 8单克隆抗体可保护小鼠免受脑型疟疾（CM）的侵害。即使在终末期疾病的小鼠中，即体温低于35。5 ℃时，用抗CDC或抗CD 8抗体或其组合治疗可防止CM，而氯喹治疗在抑制脑综合征的进一步发展方面完全无效。
The role of T-cells in development of experimental cerebral malaria was analysed in C57B1/6J and C57B1/10 mice infected with Plasmodium berghei K173 or Plasmodium berghei ANKA by treatment with anti-CD4 or anti-CD8 mAbs. Mice were protected against cerebral malaria (CM) when anti-CD4 or anti-CD8 mAbs were injected before or during infection. Even in mice in end-stage disease, i.e. with a body temperature below 35 . 5 degrees C, treatment with anti-CDC or anti-CD8 antibodies or the combination protected against CM, whereas chloroquine treatment was completely ineffective in inhibiting further development of the cerebral syndrome.