INTESTINAL PERMEABILITY AND THE PREDICTION OF RELAPSE IN CROHNS-DISEASE
INTESTINAL PERMEABILITY AND THE PREDICTION OF RELAPSE IN CROHNS-DISEASE
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DOI：
10.1016/0140-6736(93)90882-h
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发表时间：
1993-06-05
期刊：
影响因子：
168.9
通讯作者：
LOCHS, H
中科院分区：
文献类型：
--
作者：
WYATT, J;VOGELSANG, H;LOCHS, H
为了了解肠通透性（IP）是否可预测克罗恩病的复发，我们采用乳果糖-甘露醇试验测定了72例静止期克罗恩病患者的IP。患者的渗透性指数（乳果糖/甘露醇）显著高于对照组（分别为0.046 [SEM 0.005] vs 0.018 [SEM 0.002]）。患者在测试后随访1年。在37例渗透性增高的患者中，26例在试验后1年内复发，而在35例渗透性正常的患者中，仅6例在试验后1年内复发（P
To see whether intestinal permeability (IP) predicted relapse in Crohn's disease, we measured IP in 72 patients with quiescent Crohn's disease using the lactulose-mannitol test. The permeability index (lactulose/mannitol) was significantly higher in patients than in controls (0.046 [SEM 0.005] vs 0.018 [SEM 0.002], respectively). Patients were followed for 1 year after the test. 26 of the 37 patients with raised permeability, but only 6 of the 35 with normal permeability relapsed within 1 year after the test (p