Scutellaria baicalensis, a herbal medicine: Anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines
Scutellaria baicalensis, a herbal medicine: Anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines
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DOI：
10.1016/j.leukres.2006.08.019
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发表时间：
2007-04-01
影响因子：
2.7
通讯作者：
Koeffler, H. Phillip
中科院分区：
文献类型：
--
作者：
Kumagai, Takashi;Muller, Claudia I.;Koeffler, H. Phillip
黄芩（S.B.）是一种广泛使用的中草药。我们最初研究了其体外抗肿瘤活性。 S.B.通过在临床可达到的浓度下诱导细胞凋亡和细胞周期停滞来抑制 ALL、淋巴瘤和骨髓瘤细胞系的生长。抗增殖作用与线粒体损伤、Bcl 家族基因调节、CDK 抑制剂 p27 (KIPI) 水平升高和 c-myc 癌基因水平降低有关。 S.B. 的 HPLC 分析结果显示，它含有 21% 的黄芩苷，进一步研究证实它是 S.B. 的主要抗癌成分。因此，黄芩应该在这些造血系统恶性肿瘤的临床试验中进行测试。 (c) 2006 Elsevier Ltd. 保留所有权利。
Scutellariabaicalensis (S.B.) is a widely used Chinese herbal medicine. We initially investigated its in vitro anti-tumor activities. S.B. inhibited the growth of ALL, lymphoma and myeloma cell lines by inducing apoptosis and cell cycle arrest at clinically achievable concentrations. The anti-proliferative effect was associated with mitochondrial damage, modulation of the Bcl family of genes, increased level of the CDK inhibitor p27(KIPI) and decreased level of c-myc oncogene. HPLC analysis of S.B. showed it contains 21% baicalin and further studies confirmed it was the major anti-cancer component of S.B. Thus, Scutellaria baicalensis should be tested in clinical trials for these hematopoietic malignancies. (c) 2006 Elsevier Ltd. All rights reserved.