Patterns of molecular genetic variation among cat breeds
Patterns of molecular genetic variation among cat breeds
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DOI：
10.1016/j.ygeno.2007.08.008
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发表时间：
2008-01-01
期刊：
影响因子：
4.4
通讯作者：
Johnson, Warren E.
中科院分区：
文献类型：
--
作者：
Menotti-Raymond, Marilyn;David, Victor A.;Johnson, Warren E.
利用对38个猫品种进行基因分型的一组短串联重复序列（STR）基因座和对24个品种进行基因分型的284个单核苷酸多态性（SNP）来评估猫品种的遗传变异。猫品种的种群结构通常反映了它们最近的祖先和一些品种之间没有强烈的品种障碍。种群定义的稳健性有很大的范围，从表现出高定义的品种到只有三分之一遗传变异划分到单个种群的品种。利用结构算法，没有明确划分的人口细分的数量; 16个品种不能被分解成独立的群体，在建立的品种，最近开发的品种具有共同的祖先异交的后果。将这16个品种分为6个群体。在1040只猫的样本集中，96%的猫被正确地分配到它们的分类品种或品种组/种群。平均品种STR杂合性范围从中等（0.53;哈瓦那，Korat）到高（0.85;挪威森林猫，马恩岛）。猫品种的大部分变异在品种种群内观察到（83.7%），而种群间观察到的变异为16.3%。从STR和SNP数据生成的系统发育树表明，猫品种的等级关系定义不清，尽管完全或部分来自东南亚祖先的品种的地理分组是显而易见的。(C)2007爱思唯尔公司All rights reserved.
Genetic variation in cat breeds was assessed utilizing a panel of short tandem repeat (STR) loci genotyped in 38 cat breeds and 284 single-nucleotide polymorphisms (SNPs) genotyped in 24 breeds. Population structure in cat breeds generally reflects their recent ancestry and absence of strong breed barriers between some breeds. There is a wide range in the robustness of population definition, from breeds demonstrating high definition to breeds with as little as a third of their genetic variation partitioning into a single population. Utilizing the STRUCTURE algorithm, there was no clear demarcation of the number of population subdivisions; 16 breeds could not be resolved into independent populations, the consequence of outcrossing in established breeds to recently developed breeds with common ancestry. These 16 breeds were divided into 6 populations. Ninety-six percent of cats in a sample set of 1040 were correctly assigned to their classified breed or breed group/population. Average breed STR heterozygosities ranged from moderate (0.53; Havana, Korat) to high (0.85; Norwegian Forest Cat, Manx). Most of the variation in cat breeds was observed within a breed population (83.7%), versus 16.3% of the variation observed between populations. The hierarchical relationships of cat breeds is poorly defined as demonstrated by phylogenetic trees generated from both STR and SNP data, though phylogeographic grouping of breeds derived completely or in part from Southeast Asian ancestors was apparent. (C) 2007 Elsevier Inc. All rights reserved.