THROMBOTIC CEREBRAL VASCULOPATHY ASSOCIATED WITH HERPES-ZOSTER
THROMBOTIC CEREBRAL VASCULOPATHY ASSOCIATED WITH HERPES-ZOSTER
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DOI：
10.1002/ana.410190103
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发表时间：
1986-01-01
影响因子：
11.2
通讯作者：
PRICE, RW
中科院分区：
文献类型：
--
作者：
EIDELBERG, D;SOTREL, A;PRICE, RW
我们描述了3例带状疱疹后大血管脑血管病变的临床、影像和病理表现。其中两名患者在尸检时进行了研究，第三名患者进行了脑活组织检查。3例患者均出现大血管血栓闭塞，三叉神经或节段性带状疱疹感染后无明显炎症或肉芽肿改变。2例尸检患者脑血管中膜免疫过氧化物酶染色检测水痘带状疱疹病毒(VZV)抗原。与VZV抗原的病灶相关的炎症很少或没有。这些研究提供的证据表明，带状疱疹后的血管病变可能是由于血管直接感染VZV引起的，如果没有明显的炎性血管炎，感染的血管内可能会发生原位血栓形成。
We describe the clinical, radiographic, and pathological findings in 3 patients with large-vessel cerebral vasculopathy following herpes zoster. Two of the patients were studied at postmortem examination, and a brain biopsy was performed in the third. Each of the 3 patients suffered thrombotic occlusions of large vessels without notable inflammatory or granulomatous changes following trigeminal or segmental herpes zoster infection. In the 2 autopsied patients, varicella-zoster virus (VZV) antigens were detected by immunoperoxidase staining within the media of the affected cerebral arteries. Little or no inflammation was associated with the foci of the VZV antigens. These studies provide evidence that the vasculopathy following herpes zoster may result from direct VZV infection of the artery and the in situ thrombosis can develop within the infected vessels in the absence of clear inflammatory vasculitis.