Biomedical microfluidic devices by using low-cost fabrication techniques: A review
Biomedical microfluidic devices by using low-cost fabrication techniques: A review
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DOI：
10.1016/j.jbiomech.2015.11.031
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发表时间：
2016-07-26
影响因子：
2.4
通讯作者：
Minas, Graca
中科院分区：
文献类型：
--
作者：
Faustino, Vera;Catarino, Susana O.;Minas, Graca
制造生物医学微流体器件的最流行的方法之一是使用软光刻技术。然而，制造模具以生产微流体装置，例如SU-8模具，通常需要洁净室环境，这可能非常昂贵。因此，已经做出了许多努力来开发用于制造微结构的低成本替代方案，避免使用洁净室设施。最近，低成本的技术，没有洁净室设施，功能的纵横比超过20，用于制造这些SU-8模具已越来越受欢迎的生物医学研究界。在这些技术中，通常用于印刷电路板（PCB）行业的紫外线（UV）曝光设备取代了过去15年来用于SU-8图案化的更昂贵且更少可用的掩模对准器。可替代地，非光刻低成本技术由于其大规模生产的能力而增加了工业和研究界对开发简单、快速和低成本的微流体结构的兴趣。这些替代技术包括打印和剥离方法（PAP），激光喷射，固体墨水，切割绘图仪或微铣削，使用几乎所有实验室和办公室都有的设备。一个例子是xurography技术，其使用切割机和粘合剂乙烯基膜来生成主模具以制造微流体通道。在这篇综述中，我们提出了一个选择的最新的光刻和非光刻低成本技术来制造微流体结构，专注于每种技术的特点和局限性。仅考虑不需要使用洁净室的微加工方法。最后，结合实例介绍了这些微流控器件在生物医学工程中的潜在应用。(C)2015爱思唯尔有限公司版权所有。
One of the most popular methods to fabricate biomedical microfluidic devices is by using a soft lithography technique. However, the fabrication of the moulds to produce microfluidic devices, such as SU-8 moulds, usually requires a cleanroom environment that can be quite costly. Therefore, many efforts have been made to develop low-cost alternatives for the fabrication of microstructures, avoiding the use of cleanroom facilities. Recently, low-cost techniques without cleanroom facilities that feature aspect ratios more than 20, for fabricating those SU-8 moulds have been gaining popularity among biomedical research community. In those techniques, Ultraviolet (UV) exposure equipment, commonly used in the Printed Circuit Board (PCB) industry, replaces the more expensive and less available Mask Aligner that has been used in the last 15 years for SU-8 patterning. Alternatively, non-lithographic low-cost techniques, due to their ability for large-scale production, have increased the interest of the industrial and research community to develop simple, rapid and low-cost microfluidic structures. These alternative techniques include Print and Peel methods (PAP), laserjet, solid ink, cutting plotters or micromilling, that use equipment available in almost all laboratories and offices. An example is the xurography technique that uses a cutting plotter machine and adhesive vinyl films to generate the master moulds to fabricate microfluidic channels. In this review, we present a selection of the most recent lithographic and non lithographic low-cost techniques to fabricate microfluidic structures, focused on the features and limitations of each technique. Only microfabrication methods that do not require the use of cleanrooms are considered. Additionally, potential applications of these microfluidic devices in biomedical engineering are presented with some illustrative examples. (C) 2015 Elsevier Ltd. All rights reserved.