Immunosuppression of the Trimellitic Anhydride-Induced Th2 Response by Novel Nonanatural Products Mixture in Mice
Immunosuppression of the Trimellitic Anhydride-Induced Th2 Response by Novel Nonanatural Products Mixture in Mice
复制标题
新型非天然产品混合物对小鼠偏苯三酸酐诱导的 Th2 反应的免疫抑制
DOI：
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发表时间：
2013
影响因子：
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通讯作者：
D. Shon
中科院分区：
文献类型：
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作者：
Min;H. Shin;D. Shon
许多天然饮食产品预防或治愈过敏性炎症；然而，这些天然药物的混合物抑制过敏性皮肤炎症的能力尚不清楚。我们检测了非天然产物混合物(NPM-9)对Th2介导的皮肤变应性炎症的抑制作用，NPM-9提供免疫调节激活。在小鼠中口服NPM-9可以减少偏苯三酸酐(TMA-)诱导的接触性超敏反应(CHS)中的耳朵厚度和特异性IgE产生。NPM-9还抑制脾细胞中IL-4和IL-1β的产生，但仅能阻止TMA诱导的炎症耳朵中IL-1β的产生。为了确定这一效应的机制，我们检测了NPM-9对OVA诱导的Th2过敏状态的免疫抑制作用。口服NPM-9可抑制Th2介导的血清IgE的过度产生。NPM-9还下调了脾细胞中极化的Th2反应，而上调了Th1反应。这些数据表明，NPM-9可能通过抑制Th2介导的过敏反应而成为治疗变态反应性炎症性疾病的有用药物。
Many natural dietary products prevent or cure allergic inflammation; however, the ability of mixtures of these natural medicinals to suppress allergic skin inflammation is unknown. We examined the inhibitory effects of nonanatural products mixture (NPM-9), which provides immunoregulatory activation, on Th2-mediated skin allergic inflammation. Oral administration of NPM-9 in mice reduced ear thickness and specific IgE production in trimellitic anhydride- (TMA-)induced contact hypersensitivity (CHS). NPM-9 also suppressed IL-4 and IL-1β production in splenocytes but prevented only TMA-induced IL-1β production in inflamed ears. To characterize the mechanism of this effect, we examined NPM-9 immunosuppression on an OVA-induced Th2 allergic state. Oral administration of NPM-9 inhibited Th2-mediated serum IgE overproduction. NPM-9 also downregulated the polarized Th2 response, whereas it upregulated Th1 response in splenocytes. These data suggest that NPM-9 may be a useful therapeutic agent for allergic inflammatory diseases through its suppression of the Th2-mediated allergic response.
影响因子：
5.8
作者：
Youn, Hyung S.;Lee, Joo Y.;Hwang, Daniel H.
通讯作者：
Hwang, Daniel H.