Penile rehabilitation with a vacuum erectile device in an animal model is related to an antihypoxic mechanism: blood gas evidence
Penile rehabilitation with a vacuum erectile device in an animal model is related to an antihypoxic mechanism: blood gas evidence
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DOI：
10.1038/aja.2013.18
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发表时间：
2013-05-01
影响因子：
2.9
通讯作者：
Wang, Run
中科院分区：
文献类型：
--
作者：
Lin, Hao-Cheng;Yang, Wen-Li;Wang, Run
我们先前的研究表明，真空勃起装置(VED)治疗改善了双侧海绵体神经挤压(BCNC)损伤大鼠的勃起功能。本研究通过对阴茎海绵体血氧饱和度(SO2)的分析，探讨阴茎海绵体血氧饱和度(SO2)在阴茎康复中的作用机制，并探讨VED治疗对预防BCNC术后阴茎收缩的作用。成年SD大鼠30只，随机分为3组：假手术组、BCnc组和Bcnc+VED组。每周测量阴茎长度和直径。治疗4周后，用3种方法抽取阴茎血进行血气分析：方法1，在松弛状态下抽吸海绵体血；方法2，在牵引状态下抽吸海绵体血液；方法3，在应用VED后立即抽吸海绵体血液。用血气分析仪测定SO2值。结果表明，VED治疗能有效预防BCnC引起的阴茎收缩(阴茎缩短组：BCnC1.9+/-1.1 mm；VED组0.3+/-1.0 mm；P
Our previous study showed that vacuum erectile device (VED) therapy has improved erectile function in rats with bilateral cavernous nerve crush (BCNC) injuries. This study was designed to explore the mechanism of VED in penile rehabilitation by analyzing cavernous oxygen saturation (SO2) and to examine the effect of VED therapy on preventing penile shrinkage after BCNC. Thirty adult Sprague-Dawley rats were randomly assigned into three groups: group 1, sham surgery; group 2, BCNC; and group 3, BCNC+VED. Penile length and diameter were measured on a weekly basis. After 4 weeks of therapy, the penile blood was extracted by three methods for blood gas analysis (BGA): method 1, cavernous blood was aspirated at the flaccid state; method 2, cavernous blood was aspirated at the traction state; and method 3, cavernous blood was aspirated immediately after applying VED. SO2 values were tested by the blood gas analyzer. The results showed that VED therapy is effective in preventing penile shrinkage induced by BCNC (Penile shortening: BCNC group 1.9 +/- 1.1 mm; VED group 0.3 +/- 1.0 mm; P