Immunophenotyping and differential diagnosis of hairy cell leukemia
Immunophenotyping and differential diagnosis of hairy cell leukemia
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DOI：
10.1016/j.hoc.2006.06.012
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发表时间：
2006-10-01
影响因子：
2.4
通讯作者：
Matutes, Estella
中科院分区：
文献类型：
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作者：
Matutes, Estella
毛细胞白血病及其变异形式的细胞具有独特的免疫表型，似乎与成熟的活化记忆 B 细胞相对应。尽管这两种疾病在组织学和膜标志物表达方面具有相似性，例如所选的免疫球蛋白重链表达以及与某些B细胞激活标志物的反应性，但它们的临床病程、形态和免疫表型存在差异。免疫表型分析是诊断这两种疾病、监测和评估治疗反应以及将其与其他 B 细胞恶性肿瘤区分开来的重要工具。
The cells of hairy cell leukemia and its variant form have a distinct immunophenotype that seems to correspond to that of a mature activated memory B cell. Although the two diseases have similarities in histology and membrane marker expression, such as the selected immunoglobulin heavy-chain expression and the reactivity with certain B-cell activation markers, there are differences in their clinical course, morphology, and immunophenotype. Immunophenotyping is an essential tool for the diagnosis of these two disorders, for monitoring and assessing response to therapy, and for distinguishing them from other B-cell malignancies.