By C-fiber reflex inhibition by electroacupuncture with different intensities applied at homotopic and heterotopic acupoints in rats selectively destructive effects on myelinated and unmyelinated afferent fibers
By C-fiber reflex inhibition by electroacupuncture with different intensities applied at homotopic and heterotopic acupoints in rats selectively destructive effects on myelinated and unmyelinated afferent fibers
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DOI：
10.1016/j.brainres.2004.03.034
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发表时间：
2004-06-18
期刊：
影响因子：
2.9
通讯作者：
Gao, XY
中科院分区：
文献类型：
--
作者：
Zhu, B;Xu, WD;Gao, XY
本研究旨在探讨不同强度的电针在同位和异位穴位对C纤维反射的抑制作用，以及选择性损毁有髓和无髓传入纤维对C纤维反射抑制的影响。在同侧局部穴位，电针可在激活Aβ纤维的阈值以下抑制C纤维反射的一般行为。电针刺激眼镜蛇毒预处理的大鼠脱髓鞘坐骨神经的同侧肢体，在激活Aβ纤维的强度下，不能引起C纤维反射的抑制。然而，低于激活Aβ纤维阈值的异位电针则完全无效。在对侧异位穴位，只有刺激强度超过Aβ阈值和C纤维激活阈值的电针才能抑制C纤维反射。电针刺激辣椒素处理的肢体，A-纤维阈值和C-纤维激活三倍阈值强度对C-纤维反射的抑制作用较小。其抑制强度与刺激正常动物激活Aβ纤维的抑制强度大致相同。在横断T-6-T-7节段的动物中，无论强度大小，同位电针刺激只引起与激活A-β纤维相似的C-纤维反射的中度抑制，而无论作用强度如何，异位伤害性电针对C-纤维反射的抑制作用完全消失。(C)2004爱思唯尔B.V.保留所有权利。
The aims of this study were to explore the C-fiber reflex inhibition induced by electroacupuncture with different intensities applied at homotopic or heterotopic acupoints, and to determine the influence selectively destroyed myelinated and unmyelinated afferent fibers on the C-fiber reflex inhibition. In the ipsilateral local acupoint, the general behavior of the C-fiber reflex can be depressed by electroacupuncture below the threshold of Adelta-fiber activation. Electroacupuncture stimulation within the intensity of Adelta-fiber activation applied to the ipsilateral limb pretreated with cobra venom did not elicit inhibition of C-fiber reflex in rats with demyelinated sciatic nerve. However, heterotopic electroacupuncture below the threshold of Adelta-fiber activation was totally ineffective. In contralateral heterotopic acupoints, the C-fiber reflex can be depressed only by electroacupuncture with stimulating intensities exceeding thresholds of Adelta and C-fiber activation. Electroacupuncture stimuli applied to capsaicin-pretreated limb in the intensities of threshold of Adelta-fiber and treble thresholds of C-fiber activation produced only a little inhibition of C-fiber reflex. Inhibitory intensity was roughly similar to that induced by the stimulation with intensity for the activation of Adelta-fiber in normal animal. In the spinalized animals transections at T-6 - T-7 segments, regardless of intensities, the homotopic electroacupuncture stimulation only induced moderate depression of C-fiber reflex similar to that of Adelta-fiber activation; whereas, no matter what intensities of application, the inhibitory effects of C-fiber reflex disappeared totally by using heterotopic noxious electroacupuncture in these animals. (C) 2004 Elsevier B.V. All rights reserved.