Association between Overall Lifestyle Changes and the Incidence of Proteinuria: A Population-based, Cohort Study.
Association between Overall Lifestyle Changes and the Incidence of Proteinuria: A Population-based, Cohort Study.
复制标题
DOI：
10.2169/internalmedicine.56.8006
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Watanabe T
中科院分区：
文献类型：
--
作者：
Wakasugi M;Kazama J;Narita I;Iseki K;Fujimoto S;Moriyama T;Yamagata K;Konta T;Tsuruya K;Asahi K;Kondo M;Kurahashi I;Ohashi Y;Kimura K;Watanabe T
这项研究旨在研究总体健康生活方式的变化与日本普通人群中蛋白尿发生率之间的关系。一项回溯性队列研究在2008年至2009年期间在日本进行了两次健康检查的99404名(男性，36.9%)年龄在40-74岁之间的参与者中进行。所有在基线水平患有慢性肾脏疾病的参与者都被排除在外。将吸烟状况、体重指数、体育活动、饮酒和健康饮食习惯合并为一个简单的总体健康生活方式得分，范围从0到5。在第二次体检时评估总体健康生活方式得分从基线(范围-5到+5)的变化和蛋白尿的发生率(得分≥1+)。采用Logistic回归分析来检验总体健康生活方式得分的变化与蛋白尿发生率之间的关系。随访一年后，3.9%的男性和2.4%的女性出现蛋白尿。在调整了年龄、基线生活方式得分、高血压、糖尿病和高胆固醇血症后，总体健康生活方式得分的每增加(或减少)都与男性(优势比(OR)0.87；95%可信区间(CI)0.81-0.94)和女性(OR 0.87；95%CI，0.80-0.94)蛋白尿风险的降低(或增加)相关。基于年龄、有无高血压或糖尿病的分层分析得出了类似的结果。总体生活方式的改变，即使在一年内，也被发现影响蛋白尿的发生率。
This study aimed to examine the association between the changes in an overall healthy lifestyle, as quantified by the number of unhealthy lifestyle factors and obesity status, and the incidence of proteinuria in the general Japanese population. A retrospective cohort study was conducted among 99,404 (men, 36.9%) participants aged from 40-74 years of age who underwent two health check-ups with a 1-year interval in Japan between 2008 and 2009. Any participants with chronic kidney disease at baseline were excluded. The smoking status, body mass index, physical activity, alcohol consumption, and healthy eating habits were combined into a simple overall healthy lifestyle score ranging from 0 to 5. The changes in overall healthy lifestyle scores from baseline (range, -5 to +5) and the incidence of proteinuria, defined by a dipstick urinalysis (score ≥1+), were assessed at the second check-up. A logistic regression analysis was used to examine the association between the changes in overall healthy lifestyle scores and the incidence of proteinuria. After one year of follow-up, 3.9% of men and 2.4% of women developed proteinuria. Each increase (or decrease) in the changes in overall healthy lifestyle scores was associated with a reduced (or increased) risk of proteinuria in both men (odds ratio (OR) 0.87; 95% confidence interval (CI), 0.81-0.94) and women (OR 0.87; 95%CI, 0.80-0.94) after adjusting for age, baseline lifestyle scores, hypertension, diabetes mellitus, and hypercholesterolemia. Stratified analyses based on age, the presence or absence of hypertension, or diabetes mellitus revealed similar results. Overall lifestyle changes, even within a year, were found to influence the incidence of proteinuria.