Vitamins and perinatal outcomes among HIV-negative women in Tanzania
Vitamins and perinatal outcomes among HIV-negative women in Tanzania
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DOI：
10.1056/nejmoa064868
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发表时间：
2007-04-05
影响因子：
158.5
通讯作者：
Spiegelman, Donna
中科院分区：
文献类型：
--
作者：
Fawzi, Wafaie W.;Msamanga, Gernard I.;Spiegelman, Donna
早产和低出生体重与高围产期和婴儿死亡率有关，特别是在发展中国家。产妇微量营养素缺乏症可能会导致这些不良outcomes. METHODS在双盲试验在达累斯萨拉姆，坦桑尼亚，我们随机分配8468孕妇（胎龄胎儿，12至27周）谁是阴性的人类免疫缺陷病毒感染，每天接受多种维生素（包括建议的膳食津贴的倍数）或安慰剂。所有的妇女都接受了产前补充铁和叶酸。主要结果是低出生体重（
BACKGROUNDPrematurity and low birth weight are associated with high perinatal and infant mortality, especially in developing countries. Maternal micronutrient deficiencies may contribute to these adverse outcomes.METHODSIn a double-blind trial in Dar es Salaam, Tanzania, we randomly assigned 8468 pregnant women (gestational age of fetus, 12 to 27 weeks) who were negative for human immunodeficiency virus infection to receive daily multivitamins (including multiples of the recommended dietary allowance) or placebo. All the women received prenatal supplemental iron and folic acid. The primary outcomes were low birth weight (