The effect of high altitude on saliva aldosterone and glucocorticoid concentrations
The effect of high altitude on saliva aldosterone and glucocorticoid concentrations
复制标题
高海拔对唾液醛固酮和糖皮质激素浓度的影响
DOI：
--
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
J. Few
中科院分区：
文献类型：
--
作者：
C. J. McLean;C. Booth;T. Tattersall;J. Few
在肯尼亚山海拔4450 m处，分别于1-2、8-9和15-16天采集6名健康青年男子唾液，测定唾液中醛固酮（SA）和糖皮质激素（SGC，cortisol + cortisone）的浓度。血液样本与一些唾液样本同时收集，并且这些样本的分析显示醛固酮和糖皮质激素的血浆和唾液浓度高度相关（r分别为0.91和0.75;对于两种激素，p<0.01）。当在海拔高度采集第一份唾液样本时，该组的平均SA降低到海平面值的约50%（p<0.05），并在肯尼亚山的整个2周期间保持在这一低水平，尽管受试者之间存在相当大的差异。肯尼亚山的SGC浓度也往往低于海平面。虽然SA是较低的一整天在海拔高度相比，在SA的时间模式的主要区别是减少或完全没有显着的上升SA通常发生在上升后的头几个小时。SA和SGC的反应，运动，其中包括踩上和关闭0.4米高的凳子60次/分钟，25分钟，在海平面和4450米后的各个时期进行了评估。在海拔高度的SGC反应显着增强，但SA反应钝化。运动引起的SA增加与前一天或第二天的平均昼夜SA相关（r=0.74;p<0.01）。我们的数据表明，在海拔高度有一个减少醛固酮反应的肾素-血管紧张素和ACTH刺激，这表明，低压缺氧后肾小球有直接的抑制作用。他们还证明了收集唾液测量肾上腺皮质类固醇浓度在这种类型的探险，从而允许非侵入性监测肾上腺皮质活动在真实的生活情况下的有用性。
SummarySaliva was collected from six healthy young men at hourly intervals at sea level and after 1–2, 8–9 and 15–16 days at 4450 m on Mount Kenya for measurement of aldosterone (SA) and glucocorticoid (SGC, cortisol + cortisone) concentrations. Blood samples were collected simultaneously with some of the saliva samples and analysis of these showed that plasma and saliva concentrations of aldosterone and glucocorticoids were highly correlated (r=0.91 and 0.75 respectively;p<0.01 for both hormones). Mean SA for the group was reduced to approximately 50% of the sea-level value (p<0.05) by the time the first saliva samples were collected at altitude, and remained at this depressed level throughout the 2-week period on Mount Kenya, although there was considerable inter-subject variation. SGC concentration also tended to be lower on Mount Kenya than at sea level. Though SA was lower throughout the day at altitude compared to sea level, the principal difference in the temporal pattern of SA was the reduction or complete absence of the marked rise in SA that normally occurs in the first few hours after rising. SA and SGC responses to exercise, which consisted of stepping on and off an 0.4-m high stool 60 times/min for 25 min, were assessed at sea level and after various periods at 4450 m. At altitude the SGC response was significantly enhanced, but the SA response was blunted. The exercise-induced increase in SA correlated with the mean diurnal SA of the previous or next day (r=0.74;p<0.01). Our data indicate that at altitude there is a decrease in aldosterone response to both renin-angiotensin and ACTH stimulation, which suggests that hypobaric hypoxia has a direct, inhibitory effect upon the zona glomerulosa. They also demonstrate the usefulness of collecting saliva for the measurement of adrenocortical steroid concentrations during expeditions of this type, thus permitting the non-invasive monitoring of adrenocortical activity during real life situations.
慢性缺氧大鼠肺部血管紧张素 I 向血管紧张素 II 的转化受损。
DOI：
10.1152/jappl.1986.60.4.1121
发表时间：
1986
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Jackson,RM;Narkates,AJ;Oparil,S
通讯作者：
Oparil,S