Gastrin-releasing peptide receptor expression in cervical cancer
Gastrin-releasing peptide receptor expression in cervical cancer
复制标题
DOI：
10.1159/000134478
复制
发表时间：
2007-01-01
期刊：
影响因子：
3.5
通讯作者：
Schwartsmann, Gilberto
中科院分区：
文献类型：
--
作者：
Cornelio, Daniela Baumann;Meurer, Luise;Schwartsmann, Gilberto
目的：本研究的目的是评估宫颈肿瘤和邻近组织是否表达胃泌素释放肽受体（GRPR），以及其在浸润前和浸润性癌中的分布是否存在显著差异。研究方法：石蜡包埋的宫颈肿瘤（n = 88）和非肿瘤对照宫颈组织（n = 14）的切片，这些组织来自巴西波尔图阿莱格雷南里奥格兰德联邦大学学术医院病理科登记的妇女，通过免疫组织化学研究GRPR。结果：GRPR在99%的肿瘤标本中表达，大多呈弥漫性强染色。子宫颈内膜很少检测到GRPR受体，而子宫颈外膜仅在肿瘤病变附近表达GRPR。GRPR表达与浸润前和浸润性肿瘤之间无相关性。结论：据我们所知，这是第一次证明GRPR在人宫颈癌中的广泛表达。GRPR受体在肿瘤和周围组织中的存在可能表明GRPR可以在宫颈癌的发生过程中发挥作用。这些数据为利用GRPR作为宫颈肿瘤诊断和治疗目的的靶点提供了分子基础。版权所有（c）2008 S. Karger AG，巴塞尔。
Objectives: It was the aim of this study to evaluate whether cervical neoplasms and adjacent tissues express the gastrin-releasing peptide receptor (GRPR) and whether there is a significant difference in its distribution among preinvasive and invasive cancers. Methods: Sections of paraffin-embedded cervical tumors (n = 88) and non-neoplastic control cervical tissues (n = 14) obtained from women registered in the Pathology Department, Academic Hospital, Federal University of Rio Grande do Sul, Porto Alegre, Brazil, were investigated by immunohistochemistry for GRPR. Results: GRPR was detected in 99% of tumor specimens, mostly exhibiting a diffuse strong staining. The receptors were seldom detected in the endocervices, while ectocervices expressed GRPRs only when adjacent to neoplastic lesions. No correlation between GRPR expression and preinvasive and invasive neoplasms was found. Conclusions: To the best of our knowledge, this is the first demonstration of the widespread GRPR expression in human cervical cancer. The presence of receptors both in tumors and surrounding tissues may suggest that GRPR can play a role in the cervical carcinogenic process. These data provide a molecular basis for exploiting GRPR as a target for diagnostic and therapeutic purposes in cervical neoplasms. Copyright (c) 2008 S. Karger AG, Basel.