Bacterial effectors target the plant cell nucleus to subvert host transcription
Bacterial effectors target the plant cell nucleus to subvert host transcription
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DOI：
10.4161/psb.18885
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发表时间：
2012-01-01
影响因子：
2.9
通讯作者：
Rivas, Susana
中科院分区：
文献类型：
--
作者：
Canonne, Joanne;Rivas, Susana
为了提高毒力，革兰氏阴性菌已经进化出将所谓的III型效应蛋白注入宿主细胞的能力。植物细胞核似乎是细菌效应子反复靶向的亚细胞区室。与这一观察结果一致，越来越多的证据表明，操纵宿主转录是细菌对抗植物防御反应的主要策略。已经表明，细菌效应器可以采用至少三种替代的（尽管不是相互排斥的）策略来破坏宿主转录。T3 E可以（1）作为转录因子直接激活宿主细胞中的转录，（2）影响组蛋白包装和染色质构型，和/或（3）直接靶向宿主转录因子活性。在这里，我们提供了一个概述，所有这些策略可能会导致宿主转录重编程，并因此，以改善植物细胞内的细菌繁殖。
In order to promote virulence, Gram-negative bacteria have evolved the ability to inject so-called type III effector proteins into host cells. The plant cell nucleus appears to be a subcellular compartment repeatedly targeted by bacterial effectors. In agreement with this observation, mounting evidence suggests that manipulation of host transcription is a major strategy developed by bacteria to counteract plant defense responses. It has been suggested that bacterial effectors may adopt at least three alternative, although not mutually exclusive, strategies to subvert host transcription. T3Es may (1) act as transcription factors that directly activate transcription in host cells, (2) affect histone packing and chromatin configuration, and/or (3) directly target host transcription factor activity. Here, we provide an overview on how all these strategies may lead to host transcriptional re-programming and, as a result, to improved bacterial multiplication inside plant cells.