The Use of Standardized Diesel Exhaust Particles in Alzheimer's Disease Research.
The Use of Standardized Diesel Exhaust Particles in Alzheimer's Disease Research.
复制标题
DOI：
10.3233/jad-215201
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Kodavanti UP
中科院分区：
文献类型：
--
作者：
Block ML;Kodavanti UP
城市空气污染暴露如何传递阿尔茨海默病（AD）风险并影响斑块病理学的机制在很大程度上是未知的。由于颗粒物，城市空气污染的颗粒成分，在不同的地点，污染源和时间，一个单一的模型代表所有的环境颗粒物是不可行的研究调查的ar污染在中枢神经系统疾病的作用。更具体地说，为了更全面地了解颗粒物的哪些特性会影响AD，包括标准化柴油机排气颗粒物，必须采用几种颗粒物模型，并富集特定来源的组分。
The mechanisms underlying how urban air pollution exposure conveys Alzheimer’s disease (AD) risk and affects plaque pathology is largely unknown. Because particulate matter, the particle component of urban air pollution, varies across location, pollution source, and time, a single model representative of all ambient particulate matter is unfeasible for research investigating the role of ar pollution in central nervous system diseases. More specifically, the investigation of several models of particulate matter with enrichment of source-specific components are essential to employ, in order to more fully understand what characteristics of particulate matter affects AD, including Standardized Diesel Exhaust Particles.