Methylmercury exposure biomarkers as indicators of neurotoxicity in children aged 7 years
Methylmercury exposure biomarkers as indicators of neurotoxicity in children aged 7 years
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DOI：
10.1093/oxfordjournals.aje.a010002
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发表时间：
1999-08-01
影响因子：
5
通讯作者：
Keiding, N
中科院分区：
文献类型：
--
作者：
Grandjean, P;Budtz-Jorgensen, E;Keiding, N
血液或头皮头发中的汞浓度已被广泛用作甲基汞暴露的生物标志物。由于产前和产后早期暴露的风险增加，生物标志物结果必须根据年龄依赖性易感性来解释。作者比较了917名法罗群岛儿童在出生、1岁和7岁时的5组暴露生物标志物的回归系数。结果变量为1993-1994年7岁时进行的神经心理检查结果。调整协变量后，脐带血浓度与语言、注意力和记忆缺陷的关系最为密切。精细运动功能缺陷特别与分娩时母亲的头发汞有关。儿童7岁时血液和头发中的汞浓度仅是视觉空间信息记忆表现的重要预测指标。这些发现强调了脐带血汞浓度作为主要风险指标的有效性。他们还支持这样一种观点，即甲基汞神经毒性的最大易感性发生在妊娠晚期，而产后早期易感性则较少，他们认为不同的大脑功能可能存在时间依赖性易感性。
The mercury concentration in blood or scalp hair has been widely used as a biomarker for methylmercury exposure. Because of the increased risks associated with exposures during prenatal and early postnatal development, biomarker results must be interpreted with regard to the age-dependent susceptibility. The authors compared regression coefficients for five sets of exposure biomarkers in 917 children from the Faroe Islands examined at birth, 1 year, and 7 years. Outcome variables were the results of neuropsychologic examination carried out in 1993-1994 at age 7 years. After adjustment for covariates, the cord-blood concentration showed the dearest associations with deficits in language, attention, and memory. Fine-motor function deficits were particularly associated with the maternal hair mercury at parturition. Mercury concentrations in the child's blood and hair at age 7 years were significant predictors only of performance on memory for visuospatial information. These findings emphasize the usefulness of the cord-blood mercury concentration as a main risk indicator. They also support the notion that the greatest susceptibility to methylmercury neurotoxicity occurs during late gestation, while early postnatal vulnerability is less, and they suggest that the time-dependent susceptibility may vary for different brain functions.