Synthesis of well-controlled glycopolymers bearing oligosaccharides and their interactions with influenza viruses
Synthesis of well-controlled glycopolymers bearing oligosaccharides and their interactions with influenza viruses
复制标题
带有寡糖的可控糖聚合物的合成及其与流感病毒的相互作用
DOI：
10.1038/pj.2016.14
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发表时间：
2016
期刊：
影响因子：
2.8
通讯作者：
Yoshiko Miura
中科院分区：
文献类型：
--
作者：
Masanori Nagao;Yuuki Kurebayashi;Hirokazu Seto;Tomonari Tanaka;Tadanobu Takahashi;Takashi Suzuki;Yu Hoshino;Yoshiko Miura
Saccharides have a variety of different roles in living systems, such as providing energy sources and molecular recognition systems. Saccharides primarily exist on cell surfaces and facilitate the transfer of biological information between cells through the formation of interactions with specific proteins. The mechanism of this communication process is dependent on the molecular recognition ability of the saccharides, which can also have important roles in diseases, including the recognition of infectious pathogens, such as the influenza virus. 1 Pathogens recognize their host cells through the formation of specific sugar–protein interactions, where the sugar recognition proteins (lectins) on the surfaces of pathogens interact with the saccharide units on the cell surfaces. Based on the importance of these interaction mechanisms, considerable research efforts have been focused on the biological application of saccharides for the development of specific targeting systems.In living systems, the sugar–protein interactions are typically enhanced by the cluster effects (multivalent effect) of sugaraccumulated compounds. 2 By mimicking this mechanism, glycopolymers that carry pendant saccharides in their structure can exhibit strong multivalent interactions. 3–5 However, the molecular recognition properties of oligosaccharides are typically more critical than those of the corresponding monosaccharides. For example, human influenza viruses can recognize the saccharide structure of Neu5Ac (α2-6) Gal (where Neu5Ac= N-glycolylneuraminic acid and Gal= galactose). However, avian influenza viruses recognize a slightly different structure of Neu5Ac (α2-3) Gal. 1 Sialyllactoses possess these structures and have consequently been used in a wide range of applications for the influenza virus. The slight differences in the structures of oligosaccharides can play an important role in host cell recognition. Therefore, glycopolymers bearing oligosaccharides are more important for the development of novel in vivo applications, such as polymer nanomedicines, than those bearing monosaccharides.
