Humoral response to influenza vaccination in relation to pre-vaccination antibody titres, vaccination history, cytomegalovirus serostatus and CD4/CD8 ratio
Humoral response to influenza vaccination in relation to pre-vaccination antibody titres, vaccination history, cytomegalovirus serostatus and CD4/CD8 ratio
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DOI：
10.3109/23744235.2015.1135252
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发表时间：
2016-06-02
影响因子：
5.8
通讯作者：
Bengner, Malin
中科院分区：
文献类型：
--
作者：
Strindhall, Jan;Ernerudh, Jan;Bengner, Malin
一般建议老年人和慢性病患者每年接种流感疫苗，但影响结果的因素的相对重要性尚未完全了解。方法在这项研究中，88名年龄均为69岁的个体，三价灭活流感疫苗的血凝素抑制（HI）抗体的增加与接种前HI滴度、既往流感疫苗接种、巨细胞病毒血清状态以及作为免疫风险特征估计的CD 4+和CD 8 + T细胞之间的比率相关。结果预先存在的HI抗体滴度高会损害疫苗应答。对于B型流感病毒，重复接种疫苗和CD 4/CD 8比值倒置对疫苗应答有负面影响。巨细胞病毒血清阳性对接种前后HI滴度无明显影响。结论：预先存在的HI抗体和既往流感疫苗接种可能影响对流感疫苗接种的体液应答，CD 4/CD 8比值< 1可能表明对重复抗原刺激的应答能力受损。
Background Annual vaccination against influenza virus is generally recommended to elderly and chronically ill, but the relative importance of factors influencing the outcome is not fully understood. Methods In this study of 88 individuals all aged 69 years, the increase in haemagglutinin-inhibiting (HI) antibodies to trivalent inactivated influenza vaccine was correlated with HI titres before vaccination, prior vaccinations against influenza, cytomegalovirus serostatus and, as an estimate of immune risk profile, the ratio between CD4 + and CD8 + T cells. Results Vaccine responses were impaired by high pre-existing HI antibody titres. For influenza B repeated vaccinations and an inverse CD4/CD8 ratio had a negative impact on the vaccine response. Cytomegalovirus seropositivity had no apparent effect on HI titres before or after vaccination. Conclusions It is concluded that both pre-existing HI antibodies and previous vaccinations to influenza may influence the humoral response to influenza vaccination and that a CD4/CD8 ratio < 1 may indicate an impaired ability to respond to repeated antigenic stimulation.