Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E): results from the Flu Watch cohort study.
Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E): results from the Flu Watch cohort study.
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DOI：
10.12688/wellcomeopenres.15812.2
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发表时间：
2020
影响因子：
--
通讯作者：
Flu Watch Group
中科院分区：
文献类型：
--
作者：
Aldridge RW;Lewer D;Beale S;Johnson AM;Zambon M;Hayward AC;Fragaszy EB;Flu Watch Group
背景：目前有一种由新型冠状病毒SARS-CoV-2引起的大流行。第一波和第二波在英国的强度和持续时间可能取决于SARS-CoV-2在冬季的传播是否比夏季更有效，英国政府的反应部分建立在感染者将在短期内对再感染产生免疫力的假设之上。在本文中，我们从英格兰的一项前瞻性队列研究中检查了实验室确认的季节性冠状病毒（HCoV）的季节性和免疫力的证据。 研究方法：在对流感观察队列的分析中，我们检查了冬季（2006-2007年，2007-2008年，2008-2009年）和2009年H1N1流感大流行第一波期间（2009年5月至9月）所有参与者中PCR确认的冠状病毒感染（HCoV-NL 63，HCoV-OC 43和HCoV-229 E）的季节性趋势。我们还纳入了大流行和“大流行后”冬季（2009-2010年和2010-2011年）的数据，以确定两次确诊HCoV感染的个体，并检查针对同源再感染的免疫力证据。 结果：我们检测了1,104支在呼吸道疾病期间采集的拭子，并在前四个季节中检测到199支HCoV。所有季节的确诊HCoV感染率为390（95%CI 338-448）/10万人周; 2008/9年11月至3月季节最高，为674（95%CI 537-835）/10万人周。最高的发生率是在2月份，为每10万人周759例（95% CI 580-975）。2009年5月至9月期间收集的数据显示，有少量正在进行的传播，在此期间发现了4例病例。8名参与者有两次确诊感染，其中没有人两次感染同一种病毒。 结论：我们的研究结果提供的证据表明，HCoV感染在英格兰是最激烈的冬季，但有少量的持续传播在夏季期间。我们发现了一些抵抗同源再感染的免疫力。
Background: There is currently a pandemic caused by the novel coronavirus SARS-CoV-2. The intensity and duration of this first and second waves in the UK may be dependent on whether SARS-CoV-2 transmits more effectively in the winter than the summer and the UK Government response is partially built upon the assumption that those infected will develop immunity to reinfection in the short term. In this paper we examine evidence for seasonality and immunity to laboratory-confirmed seasonal coronavirus (HCoV) from a prospective cohort study in England. Methods: In this analysis of the Flu Watch cohort, we examine seasonal trends for PCR-confirmed coronavirus infections (HCoV-NL63, HCoV-OC43, and HCoV-229E) in all participants during winter seasons (2006-2007, 2007-2008, 2008-2009) and during the first wave of the 2009 H1N1 influenza pandemic (May-Sep 2009). We also included data from the pandemic and ‘post-pandemic’ winter seasons (2009-2010 and 2010-2011) to identify individuals with two confirmed HCoV infections and examine evidence for immunity against homologous reinfection. Results: We tested 1,104 swabs taken during respiratory illness and detected HCoV in 199 during the first four seasons. The rate of confirmed HCoV infection across all seasons was 390 (95% CI 338-448) per 100,000 person-weeks; highest in the Nov-Mar 2008/9 season at 674 (95%CI 537-835) per 100,000 person-weeks. The highest rate was in February at 759 (95% CI 580-975) per 100,000 person-weeks. Data collected during May-Sep 2009 showed there was small amounts of ongoing transmission, with four cases detected during this period. Eight participants had two confirmed infections, of which none had the same strain twice. Conclusion: Our results provide evidence that HCoV infection in England is most intense in winter, but that there is a small amount of ongoing transmission during summer periods. We found some evidence of immunity against homologous reinfection.