Associations between normal weight central obesity and cardiovascular disease risk factors in Japanese middle-aged adults: a cross-sectional study
Associations between normal weight central obesity and cardiovascular disease risk factors in Japanese middle-aged adults: a cross-sectional study
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DOI：
10.1186/s41043-019-0201-5
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发表时间：
2019-12-18
影响因子：
1.9
通讯作者：
Kokaze, Akatsuki
中科院分区：
文献类型：
--
作者：
Shirasawa, Takako;Ochiai, Hirotaka;Kokaze, Akatsuki
背景：一些研究表明，正常体重中心性肥胖（NWCO）与心血管疾病（CVD）的危险因素有关。然而，在日本人群中进行的研究非常有限。因此，正常体重中心性肥胖，使用身体质量指数（BMI），腰围身高比（WHtR）和CVD危险因素在中年日本成年人之间的关系进行了调查。研究对象为2013年4月至2014年3月期间在日本接受定期健康检查的40-64岁日本成年人。参与者被分为以下四组：正常体重（BMI 18.5-24.9 kg/m2）和无中心性肥胖（WHtR < 0.5）（NW）;正常体重和中心性肥胖（WHtR >= 0.5）（NWCO）;肥胖（BMI >= 25 kg/m2）和无中心性肥胖（OB）;肥胖和中心性肥胖（OBCO）。高血压定义为收缩压≥ 140 mmHg，舒张压≥ 90 mmHg，或服用高血压药物。血脂异常定义为LDL-C ≥ 140 mg/dl，HDL-C < 40 mg/dl，甘油三酯≥ 150 mg/dl，或服用血脂异常药物。糖尿病定义为空腹血糖≥ 126 mg/dl，随机血糖≥ 200 mg/dl，HbA 1c ≥ 6.5%，或接受糖尿病药物治疗。使用逻辑回归模型计算高血压、血脂异常和糖尿病的比值比（OR）和95%置信区间（CI）。结果共分析了117,163名参与者（82,487名男性和34,676名女性）。NWCO的患病率在男性中为15.6%，在女性中为30.2%。关于NW，高血压的OR（男性校正OR 1.22，95% CI 1.17-1.27，女性1.23，1.16-1.31），血脂异常（男性1.81、1.74-1.89，女性1.60、1.52-1.69）和糖尿病（男性1.35、1.25-1.46，女性1.60、1.35-1.90）在NWCO中显著较高。结论与正常体重无中心性肥胖相比，正常体重伴中心性肥胖与CVD危险因素相关，如高血压、血脂异常和糖尿病，无论性别如何。关注正常体重伴中心性肥胖对预防日本中年人心血管疾病非常重要。
Background Several studies have shown that normal weight central obesity (NWCO) is associated with cardiovascular disease (CVD) risk factors. However, studies conducted in the Japanese population have been very limited. Thus, the relationships between normal weight central obesity, classified using body mass index (BMI), the waist-to-height ratio (WHtR), and CVD risk factors in middle-aged Japanese adults were investigated. Methods The participants were Japanese adults aged 40-64 years who had undergone periodic health examinations in Japan during the period from April 2013 to March 2014. The participants were categorized into the following four groups: normal weight (BMI 18.5-24.9 kg/m(2)) and no central obesity (WHtR < 0.5) (NW); normal weight and central obesity (WHtR >= 0.5) (NWCO); obesity (BMI >= 25 kg/m(2)) and no central obesity (OB); and obesity and central obesity (OBCO). Hypertension was defined as systolic blood pressure >= 140 mmHg, diastolic blood pressure >= 90 mmHg, or taking medication for hypertension. Dyslipidemia was defined as LDL-C >= 140 mg/dl, HDL-C < 40 mg/dl, triglyceride >= 150 mg/dl, or taking medication for dyslipidemia. Diabetes was defined as fasting plasma glucose >= 126 mg/dl, random plasma glucose >= 200 mg/dl, HbA1c >= 6.5%, or receiving medical treatment for diabetes mellitus. A logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for hypertension, dyslipidemia, and diabetes. Results A total of 117,163 participants (82,487 men and 34,676 women) were analyzed. The prevalence of NWCO was 15.6% in men and 30.2% in women. With reference to NW, the ORs for hypertension (adjusted OR 1.22, 95% CI 1.17-1.27 in men, 1.23, 1.16-1.31 in women), dyslipidemia (1.81, 1.74-1.89 in men, 1.60, 1.52-1.69 in women), and diabetes (1.35, 1.25-1.46 in men, 1.60, 1.35-1.90 in women) were significantly higher in NWCO. Conclusions Normal weight with central obesity was associated with CVD risk factors, such as hypertension, dyslipidemia, and diabetes, compared with normal weight without central obesity, regardless of sex. It is important to focus on normal weight with central obesity for the prevention of CVD in Japanese middle-aged adults.