Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barre Syndrome and Abortion
Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barre Syndrome and Abortion
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DOI：
10.3389/fmicb.2018.01018
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发表时间：
2018-05-16
影响因子：
5.2
通讯作者：
Paes, Marciano, V
中科院分区：
文献类型：
--
作者：
Rabelo, Kissila;Souza, Luiz J.;Paes, Marciano, V
寨卡病毒(ZIKV)是巴西最近爆发的一种新病毒。该病毒与格林-巴利综合征(GBS)或先天性疾病之间的联系已引起全世界的关注。在这项工作中，我们调查了一例罕见的寨卡病毒病例，该病例与GBS和自发保留流产有关。利用特异的抗ZIKV染色，在胎盘(主要是霍夫鲍尔细胞)和几个胎儿组织，如脑、肺、肾、皮肤和肝脏中发现了该病毒。对胎盘和胎儿器官的组织学分析显示，不同类型的组织异常，包括胎盘的炎症、出血、水肿和坏死，以及胎儿的组织紊乱。细胞密度增加(霍夫鲍尔细胞和TCD8(+)淋巴细胞)，局部促炎细胞因子如干扰素-γ和肿瘤坏死因子-α的表达，以及其他标志物，如RANTES/CCL5和VEGFR2，支持胎盘炎症和功能障碍。母胎环节与胎儿损伤有关的承诺引起了关于母体免疫对胎儿发育的影响的讨论。这项工作中提出的发现可能有助于理解在罕见的自然流产与GBS相关的ZIKV免疫发病机制。
Zika virus (ZIKV) is an emerging virus involved in recent outbreaks in Brazil. The association between the virus and Guillain-Barre syndrome (GBS) or congenital disorders has raised a worldwide concern. In this work, we investigated a rare Zika case, which was associated with GBS and spontaneous retained abortion. Using specific anti-ZIKV staining, the virus was identified in placenta (mainly in Hofbauer cells) and in several fetal tissues, such as brain, lungs, kidneys, skin and liver. Histological analyses of the placenta and fetal organs revealed different types of tissue abnormalities, which included inflammation, hemorrhage, edema and necrosis in placenta, as well as tissue disorganization in the fetus. Increased cellularity (Hofbauer cells and TCD8(+) lymphocytes), expression of local pro-inflammatory cytokines such as IFN-gamma and TNF-alpha, and other markers, such as RANTES/CCL5 and VEGFR2, supported placental inflammation and dysfunction. The commitment of the maternal-fetal link in association with fetal damage gave rise to a discussion regarding the influence of the maternal immunity toward the fetal development. Findings presented in this work may help understanding the ZIKV immunopathogenesis under the rare contexts of spontaneous abortions in association with GBS.