Derivation of site-specific skeletal masses within the current ICRP age series.
Derivation of site-specific skeletal masses within the current ICRP age series.
复制标题
当前 ICRP 年龄系列中特定部位骨骼质量的推导。
DOI：
10.1088/0031-9155/52/11/014
复制
发表时间：
2007
影响因子：
3.5
通讯作者：
Bolch,WesleyE
中科院分区：
文献类型：
--
作者：
Watchman,ChristopherJ;Hasenauer,Deanna;Bolch,WesleyE
通常使用国际辐射防护委员会（ICRP）出版物中提供的参考质量计算骨骼辐射敏感组织的吸收剂量。这些值通常包括参考受试者年龄的总骨骼组织质量，但不包括给定年龄的个体骨部位。已知内部α粒子和β粒子发射体会发生吸收分数的部位特异性变化，在某些医疗剂量重建中，可能需要对骨髓剂量进行部位特异性估计。此外，需要骨部位特异性组织块来正确估计骨平均吸收分数，更重要的是，估计内化放射性核素和放射性药物的特异性吸收分数。在开发符合ICRP的断层扫描体模时，还需要骨骼部位的参考质量，因为该器官系统最初仅作为均匀组织区域从医学图像中分割。ICRP参考骨骼质量是根据几个独立的数据来源分配的，其中许多数据可能彼此不完全一致。在这项研究中，提出了一种方法，使用各种ICRP出版物的数据，以获得特定地点的骨骼组织质量的ICRP年龄系列的每个成员。计算活性骨髓质量，并显示与ICRP出版物70和89值的差异。骨髓内骨祖细胞的经修订的替代组织区域的新数据与其整个骨骼和不同受试者年龄的总质量的估计值一起呈现。
The calculation of absorbed dose to the radiosensitive tissues of the skeleton is routinely performed using reference masses provided in publications from the International Commission on Radiological Protection (ICRP). These values typically include total skeleton tissue masses by reference subject age, but not by individual bone site at a given age. Site-specific variations in absorbed fractions are known to occur for internal alpha-particle and beta-particle emitters, and in certain medical dose reconstructions, site-specific estimates of marrow dose may be desirable. Furthermore, bone-site-specific tissue masses are required to properly estimate skeletal-averaged absorbed fractions and, more importantly, specific absorbed fractions for internalized radionuclides and radiopharmaceuticals. Reference masses by skeletal site are also needed in the development of ICRP compliant tomographic phantoms, as this organ system is initially segmented from medical images only as a homogeneous tissue region. ICRP reference skeletal masses are assigned based upon several independent data sources, many of which may not be entirely consistent with one another. In this study, a methodology is presented, using data from the various ICRP publications, to derive site-specific skeletal tissue masses for each member of the ICRP age series. Active marrow masses are calculated and differences are shown with respect to ICRP Publications 70 and 89 values. New data for a revised surrogate tissue region for the osteoprogenitor cells within bone marrow is presented with estimates of its total mass throughout the skeleton and for different subject ages.