Nickel-Catalyzed Chemo-, Regio- and Diastereoselective Bond Formation through Proximal C-C Cleavage of Benzocyclobutenones
Nickel-Catalyzed Chemo-, Regio- and Diastereoselective Bond Formation through Proximal C-C Cleavage of Benzocyclobutenones
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DOI：
10.1002/anie.201503461
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发表时间：
2015-08-10
影响因子：
16.6
通讯作者：
Martin, Ruben
中科院分区：
文献类型：
--
作者：
Julia-Hernandez, Francisco;Ziadi, Asraa;Martin, Ruben
首次报道了苯并环丁烯酮(BCB)分子间近端C1C2裂解反应，该反应不需要预先进行羰基活化或使用贵金属。该方案在室温下工作，具有精细的化学、区域和非对映选择性特征，构成了制备一系列难以捉摸的碳环骨架的独特平台。
The first catalytic intermolecular proximal C1C2 cleavage of benzocyclobutenones (BCB) without prior carbonyl activation or employing noble metals has been developed. This protocol operates at room temperature and is characterized by an exquisite chemo-, regio- and diastereoselectivity profile, constituting a unique platform for preparing an array of elusive carbocyclic skeletons.