TEMPORAL RESOLUTION OF GAPS IN NOISE BY THE RAT IS LOST WITH FUNCTIONAL DECORTICATION
TEMPORAL RESOLUTION OF GAPS IN NOISE BY THE RAT IS LOST WITH FUNCTIONAL DECORTICATION
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DOI：
10.1037/0735-7044.105.1.33
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发表时间：
1991-02-01
影响因子：
1.9
通讯作者：
BOCIRNEA, A
中科院分区：
文献类型：
--
作者：
ISON, JR;OCONNOR, K;BOCIRNEA, A
在实验1 （n = 8）中，大鼠检测白噪声中短暂间隙的能力是通过间隙产生的声惊反射抑制来测量的，该抑制是在间隙后100 ms引起的。双侧皮质应用KCl后，长达15 ms的间隙没有反射抑制；相比之下，生理盐水对照组的抑制阈值在2 ~ 4 ms之间。在实验2 （n = 13）中，40、50或70 dB的噪声脉冲在惊吓刺激前20-500 ms呈现，在实验3 （n = 5）中，噪声偏移使惊吓刺激在2-30 ms间隔结束时呈现。噪声脉冲和补偿对生理盐水和氯化钾处理动物反射表达的抑制作用相同。噪声抵消和间隙的正常（生理盐水）功能之间的差异表明，前置时间较长，需要额外的感觉处理。应用KC1后，间隙敏感性的丧失表明，与脉冲和偏移不同，间隙处理依赖于皮质机制。
In Experiment 1 (n = 8), the rat's ability to detect brief gaps in white noise was measured by gap-produced inhibition of an acoustic startle reflex, elicited 100 ms after the gap. After bilateral application of KCl to the cortex, gaps as long as 15 ms provided no reflex inhibition; in contrast, the inhibitory threshold was between 2 and 4 ms in the saline control condition. In Experiment 2 (n = 13), noise pulses of 40, 50, or 70 dB were presented 20-500 ms before the startle stimulus, and in Experiment 3 (n = 5) noise offsets occurred so that the startle stimulus was presented at the end of a 2-30-ms gap. Noise pulses and offsets both inhibited reflex expression equally in saline- and KCl-treated animals. Differences between the normal (saline) functions of noise offsets and gaps suggest additional sensory processing with the longer lead time. The loss of gap sensitivity after KC1 application indicates that gap processing, unlike pulses and offsets, depends on cortical mechanisms.