Helicobacter pylori in North and South America before Columbus
Helicobacter pylori in North and South America before Columbus
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DOI：
10.1016/s0014-5793(02)02617-0
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发表时间：
2002-04-24
期刊：
影响因子：
3.5
通讯作者：
Graham, DY
中科院分区：
文献类型：
--
作者：
Yamaoka, Y;Orito, E;Graham, DY
我们提出了一项分子流行病学研究，基于对 1042 株幽门螺杆菌分离株的 vacA、cagA 和标签右端连接基因型的分析，表明幽门螺杆菌在哥伦布之前就已存在于新大陆。八个哥伦比亚和阿拉斯加本土菌株拥有新的 vacA 和/或 cagA 基因结构，并且与东亚幽门螺杆菌的相关性比与非亚洲幽门螺杆菌的相关性更密切。一些阿拉斯加本土菌株似乎起源于中亚，并在南美洲发现的菌株之后到达，这表明幽门螺杆菌在不同时间从亚洲穿过白令海峡到达新大陆。 (C) 2002 年由 Elsevier Science B.V. 代表欧洲生化学会联合会出版。
We present a molecular epidemiologic study, based on an analysis of vacA, cagA and tag right end junction genotypes from 1042 Helicobacter pylori isolates, suggesting that H. pylori was present in the New World before Columbus. Eight Native Colombian and Alaskan strains possessed novel vacA and/or cagA gene structures and were more closely related to East Asian than to non-Asian H. pylori. Some Native Alaskan strains appear to have originated in Central Asia and to have arrived after strains found in South America suggesting that H. pylori crossed the Bering Strait from Asia to the New World at different times. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.