HYALURONAN - RELATIONSHIP TO HEMODYNAMICS AND SURVIVAL IN PORCINE INJURY AND SEPSIS
HYALURONAN - RELATIONSHIP TO HEMODYNAMICS AND SURVIVAL IN PORCINE INJURY AND SEPSIS
复制标题
DOI：
10.1097/00003246-199209000-00020
复制
发表时间：
1992-09-01
影响因子：
8.8
通讯作者：
WALTHER, S
中科院分区：
文献类型：
--
作者：
BERG, S;JANSSON, I;WALTHER, S
背景和方法：Hybryonan是一种多糖，通常以低浓度存在于血液中，并通过肝脏迅速从血液中清除。在脓毒症患者中发现血浆透明质酸浓度增加。我们研究了48小时猪损伤和脓毒症模型中血清透明质酸浓度的变化及其与血流动力学和存活率的关系。结果：诱导实验性脓毒症后，循环透明质酸浓度升高至高值（从平均基线值242 ± 26 [SEM]至平均最大浓度964 ± 255 μ g/L [p
Background and Methods: Hyaluronan is a polysaccharide normally present in low concentrations in the blood, and is rapidly cleared from the blood by the liver. Increased plasma hyaluronan concentrations have been found in patients with sepsis. We studied changes in serum hyaluronan concentrations and their relationship to hemodynamics and survival in a 48-hr porcine model of injury and sepsis.Results: Circulating hyaluronan concentrations increased to high values after induction of experimental sepsis (from mean baseline values of 242 +/- 26 [SEM] to mean maximum concentrations of 964 +/- 255-mu-g/L [p