Dorsal and ventral rentinoic territories defined by retinoic acid synthesis, break-down and nuclear receptor expression.
Dorsal and ventral rentinoic territories defined by retinoic acid synthesis, break-down and nuclear receptor expression.
复制标题
背侧和腹侧视黄酸区域由视黄酸合成、分解和核受体表达定义。
DOI：
10.1016/s0925-4773(99)00132-x
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发表时间：
1999
影响因子：
2.6
通讯作者：
Dräger,UC
中科院分区：
文献类型：
--
作者：
McCaffery,P;Wagner,E;O'Neil,J;Petkovich,M;Dräger,UC
已知脊椎动物视网膜的背-腹侧尺寸的测定与视黄酸（RA）有关，因为高RA激活腹侧维甲酸脱氢酶的表达，而低RA激活背侧脱氢酶的表达。本研究表明，在小鼠胚胎的早期眼囊中，背侧脱氢酶的表达先于RA降解氧化酶的表达，并与之短暂重叠，在非常高的腹侧和中等高的背侧RA水平之间形成一个低谷。除了RA敏感的RARbeta在CYP26条带中下调外，大多数RA受体在整个视网膜中均匀表达。孤儿受体COUP-TFII，调节RA反应，与背脱氢酶共定位。胚胎脊椎动物视网膜按水平边界划分为背侧、腹侧区域的组织与果蝇眼盘按背侧、赤道和腹侧区域划分的组织相似，表明眼睛形态发生的相似性从单个分子延伸到地形模式。
Determination of the dorso-ventral dimension of the vertebrate retina is known to involve retinoic acid (RA), in that high RA activates expression of a ventral retinaldehyde dehydrogenase and low RA of a dorsal dehydrogenase. Here we show that in the early eye vesicle of the mouse embryo, expression of the dorsal dehydrogenase is preceded by, and transiently overlaps with, the RA-degrading oxidase creating a trough between very high ventral and moderately high dorsal RA levels. Most of the RA receptors are expressed uniformly throughout the retina except for the RA-sensitive RARbeta, which is down-regulated in the CYP26 stripe. The orphan receptor COUP-TFII, which modulates RA responses, colocalizes with the dorsal dehydrogenase. The organization of the embryonic vertebrate retina into dorsal ventral territories divided by a horizontal boundary has parallels to the division of the Drosophila eye disc into dorsal, equatorial and ventral zones, indicating that the similarities in eye morphogenesis extend beyond single molecules to topographical patterns.