Frailty: A cost incurred by reproduction?
Frailty: A cost incurred by reproduction?
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DOI：
10.1038/s41598-020-67009-2
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发表时间：
2020-06-23
影响因子：
4.6
通讯作者：
Hubbard, R. E.
中科院分区：
文献类型：
--
作者：
Gordon, E. H.;Peel, N. M.;Hubbard, R. E.
衰老的进化理论，如“一次性躯体”理论，提出自然选择用晚期生存换取早期繁殖力。“脆弱”是衡量健康状况的多维尺度，可能有助于更好地界定生育的长期后果。我们对3534名65岁及以上的成年人进行了抽样调查，这些人参加了英国老龄化纵向研究，研究了胎次和晚年虚弱之间的关系（用虚弱指数来衡量）。我们发现，产蛋最多的成年猩猩是最脆弱的，而且这种脆弱的关系在两性中是相似的。虽然这项研究提供了一些证据，证明了“生育与脆弱的权衡”，但我们的假设，即生育的生理成本影响晚年的脆弱程度，几乎没有得到支持。更确切地说，与养育许多孩子有关的行为和社会因素可能导致了男女双方身体虚弱的发展。
Evolutionary theories of senescence, such as the 'disposable soma' theory, propose that natural selection trades late survival for early fecundity. 'Frailty', a multidimensional measure of health status, may help to better define the long-term consequences of reproduction. We examined the relationship between parity and later life frailty (as measured by the Frailty Index) in a sample of 3,534 adults aged 65 years and older who participated in the English Longitudinal Study of Ageing. We found that the most parous adults were the most frail and that the parity-frailty relationship was similar for both sexes. Whilst this study provided some evidence for a 'parity-frailty trade-off', there was little support for our hypothesis that the physiological costs of childbearing influence later life frailty. Rather, behavioural and social factors associated with rearing many children may have contributed to the development of frailty in both sexes.